7'-OH-N-trityl Morpholino thyMine CAS 914361-76-5

Introduction：Basic information about 7'-OH-N-trityl Morpholino thyMine CAS 914361-76-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

7'-OH-N-trityl Morpholino thyMine Basic information

• Product Name: 7'-OH-N-trityl Morpholino thyMine
• Synonyms: 7'-OH-N-trityl Morpholino thyMine;1-((2R,6S)-6-(hydroxyMethyl)-4-tritylMorpholin-2-yl)-5-MethylpyriMidine-2,4-(1H,3H)-dione;1-[(2R,6S)-6-(Hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione;7'-Hydroxy-N-tritylmorpholino thymine monomer;1-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-5-methylpyrimidine-2, 4(1H, 3H)-dione;PMO Thymidine Precusor;PMO-T Precusor;Morpholino-5-Me-U
• CAS: 914361-76-5
• MF: C29H29N3O4
• MW: 483.56
• Mol File: 914361-76-5.mol

7'-OH-N-trityl Morpholino thyMine Chemical Properties

• density: 1.259±0.06 g/cm3(Predicted)
• pka: 9.51±0.10(Predicted)
• InChIKey: SINOYLIIFJJPCM-IZZNHLLZSA-N
• SMILES: C1(=O)N([C@@H]2O[C@H](CO)CN(C(C3=CC=CC=C3)(C3=CC=CC=C3)C3=CC=CC=C3)C2)C=C(C)C(=O)N1

7'-OH-N-trityl Morpholino thyMine Usage And Synthesis

Description

7'-OH-N-trityl Morpholino thyMine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibiting DNA synthesis, induction of apoptosis, etc.

Uses

7’-OH-N-trityl morpholinothymine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005