8-O-Acetylshanzhiside methyl ester CAS 57420-46-9

Introduction：Basic information about 8-O-Acetylshanzhiside methyl ester CAS 57420-46-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

8-O-Acetylshanzhiside methyl ester Basic information

• Product Name: 8-O-Acetylshanzhiside methyl ester
• Synonyms: (1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester;Barlerin;O-Acetyl Shanzhiside Methyl Ester, 8-;8-Acetylshanzhiside Methyl ester;UMbroside;8-O-Acetyl shanzhiside methyl ester, 98%, from Lamiophlomis rotata (Benth. ex Hook.f.) Kud
• CAS: 57420-46-9
• MF: C19H28O12
• MW: 448.42
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 57420-46-9.mol

8-O-Acetylshanzhiside methyl ester Chemical Properties

• Boiling point: 634.2±55.0 °C(Predicted)
• density: 1.52
• storage temp.: -20°C
• solubility: Soluble in methan
• form: powder
• pka: 12.80±0.70(Predicted)
• color: White
• Major Application: food and beverages
• InChIKey: ARFRZOLTIRQFCI-NGQYDJQZSA-N
• SMILES: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@@H]2OC=C([C@@H]3[C@H]2[C@](C[C@H]3O)(OC(=O)C)C)C(=O)OC

Safety Information

• Safety Statements: 24/25
• WGK Germany: WGK 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

8-O-Acetylshanzhiside methyl ester Usage And Synthesis

Chemical Properties

Off-white crystalline powder, easily soluble in methanol and ethanol, derived from unique flavor.

Uses

8-O-acetyl shanzhiside methyl ester can be used for content determination, identification and pharmacological experiments, etc. It can activate congestion, relieve pain and stop bleeding.

in vitro

Treatment of SH-SY5Y cells with 8-O-Acetyl shanzhiside methyl ester blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 ( HMGB-1) expression . Treatment of H9c2 cells with it 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.

in vivo

8-O-Acetyl shanzhiside methyl ester significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. It also significantly increases vascularization compared with vehicle treatment. 8-O-Acetyl shanzhiside methyl ester significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time , prothrombin time or thrombin time.