Acetylsalicylic acid CAS 50-78-2
Introduction：Basic information about Acetylsalicylic acid CAS 50-78-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Acetylsalicylic acid Basic informationWhat’s acetylsalicylic acid? Chemical property Uses How Aspirin is used in Ischemic Stroke therapy Production method Category Toxicity grading Acute toxicity Flammable hazardous characteristics Handling and storage characteristics Fire extinguishing agent Occupational standard
| Product Name: | Acetylsalicylic acid |
| Synonyms: | O-ACETYLSALICYLIC ACID;O-ACETOXYBENZOIC ACID;2-Acetoxybenzoesre,Aspirin;2-Acetoxybenzoic acid~Aspirin;aspirin usp;o-Acetylsalicylic acid 2-Acetoxybenzoic acid;ASPIRIN (AECTAMINOPHIN);ACETYLSALICYLIC ACID BP2000 |
| CAS: | 50-78-2 |
| MF: | C9H8O4 |
| MW: | 180.16 |
| EINECS: | 200-064-1 |
| Product Categories: | Pharmaceutical;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope;LOPROX;Anti-Allergic Agents, Antibiotic;Lipid signaling;50-78-2 |
| Mol File: | 50-78-2.mol |
Acetylsalicylic acid Chemical Properties
| Melting point | 134-136 °C (lit.) |
| Boiling point | 272.96°C (rough estimate) |
| density | 1.35 |
| refractive index | 1.4500 (estimate) |
| Fp | 250 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL at 37 °C |
| form | crystalline |
| color | white |
| pka | 3.5(at 25℃) |
| biological source | synthetic |
| Water Solubility | 3.3 g/L (20 ºC) |
| ε(extinction coefficient) | 190 at 298nm in aqueous base at 1mM 409 at 231nm in aqueous base at 1mM 466 at 230nm in aqueous acid at 1mM 68 at 278nm in aqueous acid at 1mM |
| Merck | 14,851 |
| BRN | 779271 |
| Exposure limits | ACGIH: TWA 5 mg/m3 NIOSH: TWA 5 mg/m3 |
| BCS Class | 3 |
| Stability: | Stable. Keep dry. Incompatible with strong oxidizing agents, strong bases, strong acids, various other compounds such as iodides, iron salts, quinine salts, etc. |
| Cosmetics Ingredients Functions | EXFOLIATING |
| InChI | 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) |
| InChIKey | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
| SMILES | CC(=O)Oc1ccccc1C(O)=O |
| LogP | 1.190 |
| CAS DataBase Reference | 50-78-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2-(acetyloxy)-(50-78-2) |
| EPA Substance Registry System | Aspirin (50-78-2) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN 1851 |
| OEB | B |
| OEL | TWA: 5 mg/m3 |
| WGK Germany | 1 |
| RTECS | VO0700000 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29182210 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Hazardous Substances Data | 50-78-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart) |
| What’s acetylsalicylic acid? | Acetylsalicylic acid, also known as aspirin, is an analgesic-antipyretic medicine made by salicylic acid interacting with acetic anhydride. It is a white crystalline powder, odorless, stable in dry air. It will be slowly hydrolyzed to be salicylic acid and acetic acid in moist air, and aqueous solution has acidic reaction. Slightly soluble in water, soluble in ethanol, ethyl ether, chloroform, sodium hydroxide solution and sodium carbonate solution. Acetylsalicylic acid has antipyretic analgesic, anti-inflammatory and anti-rheumatism effect, that’s why it is often used for fever, headache, muscle pain, neuralgia, rheumatic fever, acute rheumatic arthritis, gout, etc.; also it has antiplatelet aggregation effect, and can be used for prevention of arterial thrombosis, atherosclerosis, transient cerebral ischemia and myocardial infarction; in addition, acetylsalicylic acid also can be used in the treatment of biliary tract roundworm disease and athlete's foot. Pharmacological actions Acetylsalicylic acid is one of the traditional antipyretic analgesics, as well as the role of platelet aggregation. Acetylsalicylic acid in the body has the characteristics of the antithrombotic, can reduce the formation of obstructive blood clots in surrounding arteries, and inhibit release of platelet response and endogenous ADP, 5-HT, etc., therefore to inhibit second phase other than the first phase of platelet aggregation. The mechanism of action of acetylsalicylic acid is to make platelets cyclooxygenase acetylation, thus inhibiting the formation of ring peroxide, and TXA2 formation is also reduced as well. At the mean time make the platelet membrane protein acetylation, and inhibit platelet membrane enzyme, which helps to inhibit platelet function. As the cyclooxygenase is inhibited, it impacts blood vessel wall synthesized to be PGI2, the platelet TXA2 synthetic enzymes also to be inhibited; so it would impact formation of both TXA2 and PGI2 when it is large doses. Suitable for ischemic heart disease, after percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, prevent transient ischemic stroke, myocardial infarction and reduce the incidence of arrhythmia. The above information is edited by the Chemicalbook He Liao Pu. |
| Chemical property | This product is a white crystalline, with melting point 138~140 ℃, insoluble in water, soluble in alcohol, ether, etc. |
| Uses | 1.Acetylsalicylic acid is the raw material for rodenticide intermediates 4-hydroxycoumarin. 2.Used to make outdoor structural members and equipment parts exposed in highlights, such as the automobile body, agricultural machinery parts, meters and electric lamps, road marking, etc. 3.It is the earliest applied, the most popular and the most common antipyretic analgesics anti-rheumatism medicine, has aspects of pharmacological effects as antipyretic-analgesic and anti-inflammatory, anti-platelet aggregation and works quickly and effectively. Overdosage can be easily diagnosed and treated, with rare allergic reactions. Often used to cold fever, headache, neuralgia, joint ache, muscle pain, rheumatic fever, acute wet sex arthritis, rheumatoid arthritis and toothache, etc. Listed in National Essential Medicine List. Acetylsalicylic acid also works as an intermediate of other medicines. |
| How Aspirin is used in Ischemic Stroke therapy | In the therapy of Ischemic Stroke, 50 to 325 mg/day started between 24 and 48 hours after completion of alteplase has also been shown to reduce long-term death and disability. Aspirin, clopidogrel, and extended-release dipyridamole plus aspirin are all considered first-line antiplatelet agents. The combination of aspirin and clopidogrel can only be recommended in patients with ischemic stroke and a recent history of myocardial infarction or coronary stent placement and then only with ultra-low-dose aspirin to minimize bleeding risk. |
| Production method | Acetylsalicylic acid: add acetic anhydride (feeding ratio is 0.7889 times of the total salicylic acid) in reaction vessel, and then add two thirds of salicylic acid, stir it and temperature rises. React 40-60min in 81-82℃. Cool it to 81-82 ℃ and keep the temperature for 2h. When free salicylic acid is qualified, cool it to 13 ℃, precipitation crystallization, rejection filter, dry it in 65-70℃ air flow, then we get acetylsalicylic acid. |
| Category | Toxic substance |
| Toxicity grading | High toxic |
| Acute toxicity | Oral-rat LD50: 200 mg/kg; Oral-mice LD50: 250 mg/kg |
| Flammable hazardous characteristics | Flammable in fire; irritant gas would be decomposed out when heated. |
| Handling and storage characteristics | Warehouse needs to be ventiIative and dry with low temperature; separate it from oxidant and food additives. |
| Fire extinguishing agent | Water fog, foam, carbon dioxide, sandy soil. |
| Occupational standard | TWA 5 mg/m3 |
| Description | Acetylsalicylic acid is a white crystalline powder commonly known by its common name as aspirin or ASA. Aspirin is the most widely used medication in the world. |
| Chemical Properties | Acetylsalicylic acid is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti - inflammatory medication. Acetylsalicylic acid may be effective at preventing certain types of cancer, particularly colorectal cancer.The main undesirable side effects of aspirin taken by mouth are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. In children and adolescents, aspirin is no longer indicated to control flu - like symptoms or the symptoms of chickenpox or other viral illnesses, because of the risk of Reye's syndrome. Acetylsalicylic acid is part of a group of medications called non steroidal anti - inflammatory drugs (NSAIDs), but differs from most other NSAIDs in the mechanism of action. Though it, and others in its group called the salicylates, have similar effects (antipyretic, antiinflammatory, analgesic) to the other NSAIDs and inhibit the same enzyme cyclooxygenase, aspirin (but not the other salicylates) does so in an irreversible manner and, unlike others, affects more the COX-1 variant than the COX-2 variant of the enzyme. Today, aspirin is one of the most widely used medications in the world, with an estimated 40,000 tonnes of it being consumed each year . In countries where Acetylsalicylic acid is a registered trademark owned by Bayer, the generic term is acetylsalicylic acid (ASA). |
| Chemical Properties | White Solid |
| Chemical Properties | Acetylsalicylic acid is a white crystalline solid with a slightly bitter taste. It is odorless but hydrolyzes in moist air to give an acetic acid odor |
| Physical properties | Acetylsalicylic acid, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 136 °C , and a boiling point of 140 °C . Synthesis The synthesis of aspirin is classified as an esterification reaction. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH3). This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Polymorphism Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients. Many drugs are receiving regulatory approval for only a single crystal form or polymorph. For a long time, only one crystal structure for aspirin was known. That aspirin might have a second crystalline form was suspected since the 1960s. The elusive second polymorph was first discovered by Vishweshwar and coworkers in 2005 , and fine structural details were given by Bond et al. . |
| Originator | Entab,Mayrand,US,1982 |
| History | Willow leaves and bark contain salicin which is the active ingredient that dulls pain. Most histories of aspirin include four-thousand-year-old Sumerian tablets that mention willow as pain relief. It was also used by the ancient Chinese and Greeks. In the eighteenth century, Edward Stone, an English vicar used dried willow bark for five years to treat fevers. Drying it concentrates the salicin. Then in eighteen-twenty-six, Italian researchers extracted salicin from willow bark and two years later, German pharmacologist Joseph Buchner, professor of pharmacy at Munich University, Germany, succeeds in extracting the active ingredient from willow, producing bitter tasting yellow crystals that he names salicin (for willow in Latin). In 1876, the first rigorous clinical trial of salicin finds that it induces remission of fever and joint inflammation in patients with rheumatism. While working for pharmaceutical company Bayer, German chemist Felix Hoffmann finds that adding an acetyl group to salicylic acid reduces its irritant properties and Bayer patents the process and named Acetylsalicylic acid as Aspirin. |
| Uses | Acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. Acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Along with sodium salicylate (sc-3520), aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. |
| Uses | Acetylsalicylic acid's original use as an analgesic, an antipyretic, and to reduce inflammation continues to this day. More recently there is some evidence that aspirin lessens the chance of heart attacks as a result of its effect as a blood "thinner." |
| Uses | Analgesic; antipyretic; anti-inflammatory; antithrombotic |
| Uses | antifungal |
| Uses | Axepim Cephalosporin antibiotic |
| Definition | ChEBI: A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. |
| Indications | Acetylsalicylic acid is available as capsules, tablets, enteric-coatedtablets (Ecotrin), timed-release tablets (ZORprin),buffered tablets (Ascriptin, Bufferin), and as rectal suppositories.Sodium salicylate is available generically.Other salicylates include choline salicylate (Arthropan),choline magnesium trisalicylate (Trilisate), and magnesiumsalicylate (Momentum). |
| Manufacturing Process | As described in US Patent 2,731,492, a glass-lined reactor of 1,500 gallonscapacity, fitted with a water-cooled reflux condenser, thermometers withautomatic temperature registers and an efficient agitator, is employed. To start the process, a mother liquor is made by dissolving 1,532 kg of aceticanhydride (15 mols) in 1,200 kg of toluene. To this mother liquor, add 1,382kg of salicylic acid (10 mols), heat the reaction mixture under an efficientreflux condenser, to 88-92°C and maintain within this temperature range for20 hours. The reaction mixture is now transferred to aluminum cooling tanks, and isallowed to cool slowly, over a period of 3 to 4 days, to a terminal temperatureof 15-25°C (room temperature). The acetylsalicylic acid precipitates as large,regular crystals. The mother liquor is now filtered or centrifuged from theprecipitated acetylsalicylic acid and the filter cake is pressed or centrifuged asfree of mother liquor as possible. The crystals are washed with distilled wateruntil completely free of acetic acid, pressed or centrifuged as dry as possibleand the filter cake is then dried in a current of warm air at a temperature of60-70°C. The filtrate from this first batch will comprise a solution of 180 to 270 kg ofunprecipitated acetylsalicylic acid (1.0 to 1.5 mols), 510 kg of aceticanhydride (5.0 mols), 600 kg of acetic acid (10.0 mols) (obtained as a byproductin the acetylation step) and 1,200 kg of the diluent toluene. Into thisfiltrate, at a temperature of 15° to 25°C, ketene gas is now passed through asparger tube or diffuser plate, with good agitation, until a weight increase of420.5 kg of ketene (10 mols) occurs. The reaction mixture will now contain180-270 kg of unprecipitated acetylsalicylic acid (1.0-1.5 mols) and 1,532 kgof acetic anhydride (15 mols) in 1,200 kg of toluene. This mother liquor isrecycled to the first step of the process for reaction with another batch of1,382 kg of salicylic acid. On recirculating the mother liquor, the yield of pureacetylsalicylic acid is 1,780 to 1,795 kg per batch. |
| Brand name | Aspirin; Compralgyl; Melabon; Rumicine; Salipran; Spalt; Tapal; Zorprin, Acetylin (Bristol MyersSquibb, Germany), Acimetten (Pharmonta,Austria), Adprin (Pfeiffer, USA), Alka Seltzer(Bayer, Austria, Switzerland, Czech Republic),Angettes (Bristol-Myers, UK), Asaped (Sanofi-Winthrop, USA),Aspro (Roche Nicholas, Germany), Colfarit(Bayer Pharma Deutschland, Germany), . |
| Therapeutic Function | Analgesic, Antipyretic, Antiinflammatory |
| World Health Organization (WHO) | Acetylsalicylic acid, a nonsteroidal anti-inflammatory, analgesic andantipyretic agent, was introduced into medicine in 1899 and has since been widelyavailable in over-the-counter preparations. Recent studies carried out in the USAhave shown an association between acetylsalicylic acid consumption in children andthe development of Reye's syndrome (a rare condition characterized by acombination of encephalopathy and liver disorder and usually preceded by an acuteviral illness, such as influenza, diarrhoea, or chickenpox). Many drug regulatoryauthorities have acted to caution against the use of the drug in children and youngadults with febrile conditions. Even within this group the risk of exposure is remoteand has been estimated to be of the order of 1.5 per million. This warning alsoconcerns products containing other salicylates. The new indication of acetylsalicylicacid - prophylaxis of myocardial infarction due to its antithrombotic effect - requiresloneterm use and may lead to serious adverse reactions, including cerebralhaemorrhage. Acetylsalicylic acid retains a valuable place in medicine and remains inthe WHO Model List of Essential Drugs. |
| Biological Functions | Acetylsalicylic acid is one of the most important NSAIDs becauseit decreases pain at predominantly peripheralsites with little cortical interaction and thus has fewCNS effects. The prototypical COX-2 inhibitors arecelecoxib (Celebrex) and its chemical cousin, rofecoxib(Vioxx). In addition to a role in inflammatory processes,COX-2 seems to play a role in colon cancer andAlzheimer’s disease, providing potential additional usesfor COX-2-selective drugs. |
| Acquired resistance | Acetylsalicylic acid is rapidly absorbed in the stomach and quickly degraded by plasma cholinesterases(half-life, 15–20 min). A once-daily dose of 160 mg of aspirin, which is much lower than dosagesneeded for its anti-inflammatory/analgesic actions, is sufficient to completely inactivate plateletCOX-1 irreversibly. Higher doses of aspirin only contribute to its side effects, especiallyinternal bleeding and upper gastrointestinal irritations. |
| General Description | Odorless white crystals or crystalline powder with a slightly bitter taste. |
| General Description | Acetylsalicylic acid (Aspro, Empirin), was introducedinto medicine by Dreser in 1899.Acetylsalicylic acid occurs as white crystals or as a white crystallinepowder and must be kept under dry conditions. It is not advisableto keep Acetylsalicylic acid products in the kitchen or bathroomcabinets, because Acetylsalicylic acid is slowly decomposed into aceticand salicylic acids in the presence of heat and moisture.Several proprietaries (e.g., Bufferin) use compounds such as sodium bicarbonate, aluminum glycinate, sodium citrate,aluminum hydroxide, or magnesium trisilicate to counteractAcetylsalicylic acid’s acidic property. One of the better antacids is dihydroxyaluminumaminoacetate. Acetylsalicylic acid is unusually effectivewhen prescribed with calcium glutamate. The more stable,nonirritant calcium acetylsalicylate is formed, and theglutamate portion (glutamic acid) maintains a pH of 3.5 to5. Practically all salts of Acetylsalicylic acid, except those of aluminumand calcium, are unstable for pharmaceutical use. Thesesalts appear to have fewer undesirable side effects and induceanalgesia faster than Acetylsalicylic acid. A timed release preparationof Acetylsalicylic acid is available. It does not appear to offer anyadvantages over Acetylsalicylic acid, except for bedtime dosage. |
| General Description | Acetylsalicylic acid has an inhibitoryeffect on platelet aggregation not only because of its abilityto inhibit cyclooxygenase (COX) but also because of its ability to acetylate the enzyme. Acetylsalicylic acid irreversibly inhibitsCOX (prostaglandin H synthase), which is the enzyme involvedin converting arachidonate to prostaglandin G2 andultimately thromboxane 2, an inducer of platelet aggregation. Acetylsalicylic acid's mechanism of action includes not only the inhibitionin the biosynthesis of thromboxane 2, but also itsability to acetylate the serine residue (529) in the polypeptidechain of platelet prostaglandin H synthetase-1. Thisexplains why other nonsteroidal anti-inflammatory agentsthat are capable of inhibiting the COX enzyme do not act asantithrombotics—they are not capable of acetylating thisenzyme. Because platelets cannot synthesize new enzymes, Acetylsalicylic acid's ability to acetylate COX lasts for the life of theplatelet (7–10 days) and is, thus, irreversible. |
| Air & Water Reactions | Slowly hydrolyzes in moist air. Has been involved in dust cloud explosions. Water insoluble. Solution in water is acid to methyl red indicator. |
| Reactivity Profile | The active ingredient in common aspirin. Incompatible with oxidizers and strong acids. Also incompatible with strong bases. May react with water or nucleophiles (e.g. amines and hydroxy groups). May also react with acetanilide, amidopyrine, phenazone, hexamine, iron salts, phenobarbitone sodium, quinine salts, potassium and sodium iodides, alkali hydroxides, carbonates, stearates and paracetanol. |
| Hazard | An allergen; may cause local bleeding espe-cially of the gums; 10-g dose may be fatal. Maycause excessive biosynthesis of prostaglandins.Dust dispersed in air is serious explosion risk. Skinand eye irritant. |
| Fire Hazard | Acetylsalicylic acid is combustible. |
| Biochem/physiol Actions | Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors. |
| Mechanism of action | Discovery of the mechanism In 1971, British pharmacologist John Robert Vane, then employed by the Royal College of Surgeons in London, showed Acetylsalicylic acid suppressed the production of prostaglandins and thromboxanes.Suppression of prostaglandins and thromboxanesAcetylsalicylic acid's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclo oxygenase (PTGS) enzyme required for prostaglandin and thromboxane synthesis. Acetylsalicylic acid acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme.COX-1 and COX-2 inhibitionThere are at least two different types of cyclooxygenase: COX-1 and COX-2. Acetylsalicylic acid irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory. Acetylsalicylic acid-modified PTGS2 produces lipoxins, most of which are anti-inflammatory.Additional mechanismsAcetylsalicylic acid has been shown to have at least three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons . In short, Acetylsalicylic acid buffers and transports the protons. When high doses of Acetylsalicylic acid are given, it may actually cause fever, owing to the heat released from the electron transport chain, as opposed to the antipyretic action of Acetylsalicylic acid seen with lower doses.Hypothalamic - pituitary - adrenal activityAcetylsalicylic acid, like other medications affecting prostaglandin synthesis, has profound effects on the pituitary gland, which indirectly affects a number of other hormones and physiological functions. |
| Pharmacology | Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is poorly soluble in the acidic conditions of the stomach, which can delay absorption of high doses for eight to 24 hours. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed rapidly there, which in turn allows more of the salicylate to dissolve. Owing to the issue of solubility, however, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion. |
| Pharmacology | Although Acetylsalicylic acid itself is pharmacologically active, it is rapidly hydrolyzed to salicylic acid after its absorption, and it is the salicylate anion that accounts for most of the anti-inflammatory activity of the drug. The superior analgesic activity of Acetylsalicylic acid compared with sodium salicylate implies that Acetylsalicylic acid has an intrinsic activity that is not totally explainable by its conversion to salicylic acid. Acetylsalicylic acid inhibits COX-1 to a much greater extent than COX-2; sodium salicylate is more selective for COX-1. This, combined with the ability of Acetylsalicylic acid to acetylate proteins, might account for some of the therapeutic and toxicological differences between Acetylsalicylic acid and the other salicylates.The binding of salicylic acid to plasma proteins varies with its plasma concentrations. At serum salicylic acid concentrations of less than 100 μg/mL, 90 to 95% is protein bound; at 100 to 400 μg/mL, 70 to 85% is protein bound; and at concentrations greater than 400 μg/mL, 20 to 60% is protein bound. The plasma concentration of salicylate that is associated with antiinflammatory activity (200–300 μg/mL) is about six times that needed to produce analgesia. At these higher concentrations, salicylate metabolism is reduced, resulting in a longer half-life for the drug. This reaction is a consequence of the saturable enzyme systems that metabolize salicylates. The plasma half-life for salicylate has been estimated to be 3 to 6 hours at the lower (analgesic) dosage and 15 to 30 hours at the higher (antiinflammatory) dosages.The rate of hydrolysis of Acetylsalicylic acid to salicylic acid is not dose limited, and no differences in the absorption of Acetylsalicylic acid have been observed between arthritic patients and normal individuals. |
| Clinical Use | Acetylsalicylic acid is used in the treatment of a number of conditions, including fever, pain, rheumatic fever, and inflammatory diseases, such as rheumatoid arthritis, pericarditis, and Kawasaki disease.PainAsprin 325 MG for pain In most cases, Acetylsalicylic acid is considered inferior to ibuprofen for the alleviation of pain, because Acetylsalicylic acid is more likely to cause gastrointestinal bleeding . Acetylsalicylic acid is generally ineffective for those pains caused by muscle cramps, bloating, gastric distension, or acute skin irritation.HeadacheAcetylsalicylic acid, either by itself or in combined formulation, effectively treats some types of headache, but its efficacy may be questionable for others.Acetylsalicylic acid or other overthe- counter analgesics are widely recognized as effective for the treatment of tension headache. Acetylsalicylic acid, especially as a component of an acetaminophen/Acetylsalicylic acid/caffeine formulation (e.g., Excedrin Migraine), is considered a first - line therapy in the treatment of migraine, and comparable to lower doses of sumatriptan.FeverLike its ability to control pain, Acetylsalicylic acid's ability to control fever is due to its action on the prostaglandin system through its irreversible inhibition of COX .Heart attacks and strokesFor a subset of the population, Acetylsalicylic acid may help prevent heart attacks and strokes. In lower doses, Acetylsalicylic acid has been known to prevent the progression of existing cardiovascular disease, and reduce the frequency of these events for those with a history of them . ( This is known as secondary prevention.)Post-surgeryAfter percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent, a US Agency for Healthcare Research and Quality guideline recommends that Acetylsalicylic acid be taken indefinitely.Frequently, Acetylsalicylic acid is combined with an ADP receptor inhibitor, such as clopidogrel, prasugrel or ticagrelor to prevent blood clots. This is called dual anti-platelet therapy (DAPT). |
| Side effects | ContraindicationsAcetylsalicylic acid should not be taken by people who are allergic to ibuprofen or naproxen , or who have salicylate intolerance[70][71] or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID - precipitated bronchospasm.GastrointestinalAcetylsalicylic acid use has been shown to increase the risk of gastrointestinal bleeding . Although some enteric-coated formulations of Acetylsalicylic acid are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk. Combining Acetylsalicylic acid with other NSAIDs has also been shown to further increase this risk.Central effectsLarge doses of salicylate, a metabolite of Acetylsalicylic acid, have been proposed to cause tinnitus (ringing in the ears) based on experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.Reye syndrome Reye syndrome, a rare but severe illness characterized by acute encephalopathy and fatty liver, can occur when children or adolescents are given Acetylsalicylic acid for a fever or other illnesses or infections. |
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