Introduction：Basic information about Adenosine 5'-monophosphate disodium salt CAS 4578-31-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Adenosine 5'-monophosphate disodium salt Basic information
| Product Name: | Adenosine 5'-monophosphate disodium salt |
| Synonyms: | 5’-adenylicacid,disodiumsalt;adenylicaciddisodiumsalt;disodium5’-amp;ADENOSINE-5-MONOPHOSPHATENA2;ADENOSINE-5''-MONOPHOSPHATE DISODIUM SALT (AMP);ADENOSINE-5-MONO PHOSPHATE DISODIUM SALT (AMP-Na2) extrapure for biochemistry;AMP disodium;Disodium AMP |
| CAS: | 4578-31-8 |
| MF: | C10H15N5NaO7P |
| MW: | 371.22 |
| EINECS: | 224-961-2 |
| Product Categories: | Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Nucleic acids;Pharmaceutical Intermediates;Pharmaceutical;4578-31-8;Nucleotide |
| Mol File: | 4578-31-8.mol |
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Adenosine 5'-monophosphate disodium salt Chemical Properties
| Melting point | 232-235°C |
| FEMA | 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: soluble |
| form | crystalline |
| color | White |
| Odor | Odorless |
| Optical Rotation | [α]20/D 43±2°, c = 1% in 0.5 M Na2HPO4 (dry matter) |
| biological source | microbial (Candida utilis)
synthetic |
| Water Solubility | Soluble in water, dimethyl sulfoxide and methanol. |
| BRN | 3586732 |
| Stability: | Hygroscopic |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | PUKWBWWOVFJXQS-JHVGCDEENA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,11,r| |
| CAS DataBase Reference | 4578-31-8(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | AU7481600 |
| F | 1-10 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
Adenosine 5'-monophosphate disodium salt Usage And Synthesis
| Description | Adenosine 5'-monophosphate disodium salt is a modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. Adenosine 5'-monophosphate disodium salt is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase, AMP deaminase and 5?-nucleotidase. |
| Chemical Properties | White powder |
| Uses | Adenosine 5'-monophosphate disodium salt is useful for skin rejuvenation in dermatology and aesthetic dermatology. |
| Uses | Adenosine-5'-monophosphate disodium salt is a nucleotide involved in the reactions of cellular energy transfers. It is useful for skin rejuvenation in dermatology and aesthetic dermatology. It acts as an activator of a class of protein kinases called as AMP-activated protein kinase (AMPK). Further, it is used as a substrate for enzymes such as AMP-thymidine kinase, AMP deaminase and 5'-nucleotidase. |
| Definition | ChEBI: Adenosine 5'-phosphate disodium is an organic molecular entity. |
| Biological Functions | Research indicates that an emulsion containing 3% Adenosine 5'-monophosphate disodium salt (AMP-NA2) safely accelerates human stratum corneum renewal. AMP-Na₂ exhibits dual characteristics in the proliferation of primary cultured keratinocytes: inducing cell growth at low concentrations whilst inhibiting it at high concentrations. It further promotes cell cycle progression in the basal layer of hairless rat epidermis. Research suggests topical AMP-Na₂ achieves mild penetration into the epidermal basal layer, where its low-concentration environment facilitates cell cycle advancement.
[1] FUKUMI FURUKAWA. Effects of adenosine 5′-monophosphate on epidermal turnover[J]. Archives of Dermatological Research, 2008, 300 9: 485-493. DOI:10.1007/s00403-008-0882-x.
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| General Description | Adenosine 5'-monophosphate disodium salt(AMP-2Na) is an orally active purine nucleotide, and participates in ATP metabolism. AMP-2Na is also a ligand for adenosine 2B receptor. AMP-2Na can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. AMP-2Na can be used for research of diabetes. |
Adenosine 5'-monophosphate disodium salt Preparation Products And Raw materials
| Raw materials | Adenosine |
| Preparation Products | Uridine 5′-monophosphate disodium salt |
