CAS 36396-99-3|N6-Cyclohexyladenosine
| Common Name | N6-Cyclohexyladenosine | ||
|---|---|---|---|
| CAS Number | 36396-99-3 | Molecular Weight | 349.38500 |
| Density | 1.71g/cm3 | Boiling Point | 675.2ºC at 760mmHg |
| Molecular Formula | C16H23N5O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 362.1ºC |
Names
| Name | (2R,3R,4S,5R)-2-(6-(Cyclohexylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
|---|---|
| Synonym | More Synonyms |
N6-Cyclohexyladenosine BiologicalActivity
| Description | N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM). IC50 value: 8.2 nM (EC50)Target: A1 receptorin vivo: N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor effects of lumbar sympathetic nerve stimulation in rats. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Adenosine ReceptorResearch Areas >>Neurological Disease |
| References | [1]. Asghari AA, et al. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J Neurol Sci. 2013 Feb 15;3 |
Chemical & Physical Properties
| Density | 1.71g/cm3 |
|---|---|
| Boiling Point | 675.2ºC at 760mmHg |
| Molecular Formula | C16H23N5O4 |
| Molecular Weight | 349.38500 |
| Flash Point | 362.1ºC |
| Exact Mass | 349.17500 |
| PSA | 125.55000 |
| LogP | 0.25540 |
| Index of Refraction | 1.787 |
| InChIKey | SZBULDQSDUXAPJ-XNIJJKJLSA-N |
| SMILES | OCC1OC(n2cnc3c(NC4CCCCC4)ncnc32)C(O)C1O |
| Storage condition | 2-8℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles34
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| IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem. Biophys. Res. Commun. 449(4) , 477-82, (2014) Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection aft... | |
| The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice. Neuropharmacology 72 , 1-8, (2013) Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in va... |
Synonyms
| N6-Cyclohexyladenosine |
