Introduction：Basic information about Alibendol CAS 26750-81-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Alibendol Basic information
| Product Name: | Alibendol |
| Synonyms: | hydroxy-2methoxy-3allyl-5n-(beta-hydroxyethyl)benzamide;Alibendol ,2-hydroxy-3-methoxy-5-allyl-N-(C-hydroxyethyl)-benzamide;5-Allyl-2-hydroxy-N-(2-hydroxyethyl)-3-methoxybenzamide;5-Allyl-N-(2-hydroxyethyl)-3-methoxysalicylamide;Cebera;H-3774;PC-54;2-hydroxy-N-(2-hydroxyethyl)-3-methoxy-5-prop-2-enylbenzamide |
| CAS: | 26750-81-2 |
| MF: | C13H17NO4 |
| MW: | 251.28 |
| EINECS: | 247-960-9 |
| Product Categories: | Inhibitors;Aromatics;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 26750-81-2.mol |
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Alibendol Chemical Properties
| Melting point | 97-99°C |
| Boiling point | 402.4±45.0 °C(Predicted) |
| density | 1.192±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 8.59±0.48(Predicted) |
| color | White |
| λmax | 316nm(EtOH)(lit.) |
| Merck | 14,244 |
| CAS DataBase Reference | 26750-81-2(CAS DataBase Reference) |
Safety Information
| RTECS | CU8730000 |
| HS Code | 2924.29.7790 |
| Toxicity | LD50 in Swiss male mice (mg/kg): >3000 orally; >2000 s.c.; 209 i.p.; 217 i.v. (Clémence) |
Alibendol Usage And Synthesis
| Chemical Properties | White Solid |
| Originator | Cebera ,Bouchara ,France ,1981 |
| Uses | Alibendol is an antispasmodic,choleretic, and cholekinetic. |
| Uses | An amide analog of Eugenol, and is used therapeutically as an antispasmodic. |
| Definition | ChEBI: Alibendol is a member of salicylamides. |
| Manufacturing Process | 36 g of ethyl ester of 2-hydroxy-3-methoxy-5-allyl-benzoic acid [obtained bythe process described by Pearl, et al., J. Amer. Chem. Soc., Vol. 71, 1067-1068 (1949)] and 61 g of ethanolamine were admixed and left to stand for 1hour at ambient temperature after which it was heated for 1 hour at 120°C.The mixture was extracted with chloroform and the organic phases werewashed with half diluted hydrochloric acid, then with water, and thechloroform evaporated off. The residue, after recrystallization from benzene,was a 78% yield of 2-hydroxy-3-methoxy-5-allyl-N-(β-hydroxyethyl)-benzamide having a melting point of 95°C. The product appeared in the formof colorless crystals which were insoluble in water and soluble in dilute sodiumhydroxide. |
| Therapeutic Function | Choleretic, Spasmolytic |
Alibendol Preparation Products And Raw materials
| Raw materials | Monoethanolamine-->Ethyl benzoate-->4-propylbenzoic acid-->Ethanol |
