Introduction：Basic information about ALPHA-CGRP (8-37) (HUMAN) CAS 119911-68-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
ALPHA-CGRP (8-37) (HUMAN) Basic information
| Product Name: | ALPHA-CGRP (8-37) (HUMAN) |
| Synonyms: | calcitoningene-relatedpeptide(8-37;VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2;Alpha-CGRP (8-37) (human) trifluoroacetate salt;calcitonin gene related peptide*fragment 8-37 hum;A-CGRP (8-37) (HUMAN);α-cgrp 8-37;ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7;8-Val-37-Phe-calcitonin gene-related peptide |
| CAS: | 119911-68-1 |
| MF: | C139H230N44O38 |
| MW: | 3125.59 |
| EINECS: | 232-693-2 |
| Product Categories: | Peptide;Calcitonin and CGRP receptor |
| Mol File: | 119911-68-1.mol |
|
ALPHA-CGRP (8-37) (HUMAN) Chemical Properties
| density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | powder |
| color | White to off-white |
| Water Solubility | Soluble to 0.50 mg/ml in sterile water |
| Sequence | H-Val-Thr-His-Arg-Leu-Ala-Asp-Phe-Leu-Ser-Arg-Ser-Gly-Gly-Val-Gly-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 |
| InChIKey | NDACAFBDTQIYCQ-YVQXRMNASA-N |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
ALPHA-CGRP (8-37) (HUMAN) Usage And Synthesis
| Uses | Calcitonin Gene Related Peptide Fragment 8-37 human has been used in the administration of drugs. It has been used to test the hypothesis that calcitonin gene‐related peptide (CGRP) plays a role in the fetal cardiovascular and metabolic defense responses to acute hypoxaemia by affecting sympathetic outflow. |
| General Description | Calcitonin-related peptide α (CALCA) is a 37-amino-acid vasoactive neuropeptide. It is scattered in the central and peripheral nervous systems. The calcitonin/calcitonin gene-related peptide gene complex codes for a small family of peptides: calcitonin, katacalcin and CALCA. This vasodilator is potent than other vasodilators, such as adenosine, substance P or acetylcholine. CALCA gene is located on human chromosome 11p15.2-p15.1. Procalcitonin (PCT) is a calcitonin (CT) precursor. |
| Biochem/physiol Actions | Selective competitive antagonist at CGRP receptors, but not at calcitonin receptors.Calcitonin gene-related peptide (CALCA) serves as a proangiogenic growth factor in the development of human placenta. Mutations of CALCA gene is associated with Parkinson′s disease, ovarian cancer and essential hypertension. CALCA induce vascular endothelial cell proliferation, migration and capillary-like tube formation. |
| storage | Store at -20°C |
ALPHA-CGRP (8-37) (HUMAN) Preparation Products And Raw materials
