Apramycin sulfate CAS 65710-07-8

Introduction：Basic information about Apramycin sulfate CAS 65710-07-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Apramycin sulfate Basic information

• Product Name: Apramycin sulfate
• Synonyms: APRAMYCIN SULPHATE;APRAMYCIN SULFATE SALT;5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL;NEBRAMYCIN II SULFATE;ApraMycin sulf;Apramycin sulfate solution,1000ppm;D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:);Apramycin sulfate Solution Solution, 100ppm
• CAS: 65710-07-8
• MF: C21H43N5O15S
• MW: 637.66
• EINECS: 265-890-7
• Product Categories: SOLODYN;antibiotic;Amines;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;Active Pharmaceutical Ingredients;Peptide Synthesis/Antibiotics;Inhibitors
• Mol File: 65710-07-8.mol

Apramycin sulfate Chemical Properties

• Melting point: >168°C (dec.)
• Boiling point: 823℃
• density: 1.56
• Fp: 451.6°(845°F)
• storage temp.: Inert atmosphere,2-8°C
• solubility: H2O: soluble25mg/mL
• form: powder
• color: white to light yellow
• Water Solubility: Soluble in water.
• JECFA Number: 75
• InChIKey: WGLYHYWDYPSNPF-RQFIXDHTSA-N
• SMILES: OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

Safety Information

• Hazard Codes: T,Xn
• Risk Statements: 61-35-36/37/38-20/21/22-36/38
• Safety Statements: 53-26-36/37/39-45-36
• WGK Germany: 3
• F: 10
• HS Code: 29419000
• Storage Class: 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Repr. 1B

Apramycin sulfate Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

antibacterial; LD50(iv) 280mg/kg(mouse)

Uses

Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

Uses

Apramycin sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.

Definition

ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol.

in vivo

Apramycin (200 mg/kg/d, s.c., 9 d) sulfate demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice^[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) sulfate dose-dependently reduces bacterial burden in the kidneys between 2-5 log₁₀ and in blood between 2-3 log₁₀ for neutropenic model of Staphylococcus aureus septicemia mice^[2].
Apramycin (50 mg/kg/d, s.c., 21 d) sulfate induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)^[3].

• Animal Model: M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice ^[2]
• Dosage: 200 mg/kg/d
• Administration: Subcutaneousinjection (s.c.) for 9 d
• Result: Showed a 2.4-log₁₀ CFU reduction and better antituberculous activity compared to Amikacin (1.8-log₁₀ reduction).

IC 50

Aminoglycoside