Introduction：Basic information about Argipressine CAS 113-79-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Argipressine Basic information
| Product Name: | Argipressine |
| Synonyms: | [ARG8]-VASOPRESSIN (HUMAN, BOVINE, OVINE, RAT, MOUSE);[ARG8]-VASOPRESSIN;[ARG8]-VASOPRESSIN (AVP);ANTIDIURETIC HORMONE;AVP;BETA-HYPOPHAMINE;β-Hypophamine;(ARG8)-VASOPRESSIN GRADE VI SOLUTION*APP ROX. 100 I. |
| CAS: | 113-79-1 |
| MF: | C46H65N15O12S2 |
| MW: | 1084.24 |
| EINECS: | 204-035-4 |
| Product Categories: | Amino Acid Derivatives;Vasopressin and Oxytocin receptor;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;Peptide Receptors;Peptide;113-79-1 |
| Mol File: | 113-79-1.mol |
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Argipressine Chemical Properties
| density | 1.59±0.1 g/cm3(Predicted) |
| Fp | 113℃ |
| storage temp. | 2-8°C |
| pka | 9.90±0.15(Predicted) |
| form | Solid |
| color | White to off-white |
| PH | ~3.5 |
| Optical Rotation | -23.822 (1 mol dm-3 acetic acid) |
| biological source | synthetic (organic) |
| Water Solubility | Water : ≥ 360 mg/mL (332.03 mM) |
| Sequence | H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2，(Disulfide bond) |
| InChIKey | KBZOIRJILGZLEJ-KIIOGHSHNA-N |
| SMILES | NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 20 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| HS Code | 2937190000 |
| Storage Class | 10 - Combustible liquids |
| Toxicity | TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000 |
Argipressine Usage And Synthesis
| Uses | Hormone (antidiuretic). |
| Uses | [Arg8]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies. |
| Definition | ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. |
| Indications | ADH (vasopressin) is released primarily in response toincreases in plasma osmolarity or decreases in bloodvolume. It produces its antidiuretic activity in the kidney,causing the cortical and medullary parts of the collectingduct to become more permeable to water,thereby increasing water reabsorption, reducing serumosmolarity, and increasing its volume. It produces thiseffect by binding to a subset of vasopressin receptors called V2 that have relatively high affinityfor the hormone. ADH also has actions at sites otherthan the kidney. V2 receptors also mediate an increasein circulating levels of two proteins involved in bloodcoagulation: factor VIII and von Willebrand’s factor.Athigher concentrations, ADH interacts with V1 receptorsto cause a general constriction of most blood vessels. Italso interacts with V3 (or V1b) receptors to increaseACTH release, although the major control of ACTH releaseoccurs through corticotropin-releasing hormone. |
| Brand name | Pitressin(Parke-Davis). |
| General Description | Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously. |
| Hazard | A poison. |
| Biochem/physiol Actions | [Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH. |
| Mechanism of action | ADH itself is available for injections (Pitressin) buthas a half-life of about 15 minutes. Desmopressin(DDAVP) is an analogue without an amino group atthe first amino acid and with D-arginine instead of Larginine.This analogue is more stable and has very littlepressor activity. Desmopressin can be given subcutaneouslyor nasally, and the effects last for 12 hours. |
| Clinical Use | Because it is stable, desmopressin is preferred fortreatments especially if pressor effects are not desired.The primary indication for therapy is central diabetesinsipidus, a disorder that results when ADH secretion isreduced and that is characterized by polydipsia,polyuria, and dehydration. Desmopressin is also used toreduce primary nocturnal enuresis, or bedwetting, inchildren. It is useful in people with mild hemophilia Aor with some types of von Willebrand’s disease, in whichvon Willebrand’s factor is present at low levels. In thesecases, desmopressin is given when excessive bleedingoccurs or before surgery to help reduce bleeding indirectlyby increasing the amounts of coagulation factors.A possible adverse effect of desmopressin is water intoxicationif too much is taken.
ADH antagonists, including nonpeptide analoguesthat may be taken orally, have been developed withspecificity for each of the receptor types. In the future,those that block V1 receptors may be useful in treatinghypertension, and those that block V2 receptors may beuseful in any condition of excessive water retention orhyponatremia, for which so far there is no satisfactorytherapeutic treatment. |
| Safety Profile | A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx. |
| storage | Store at -20°C |
Argipressine Preparation Products And Raw materials
| Preparation Products | long-acting vasopressinl |
