Introduction：Basic information about Asiaticoside CAS 16830-15-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Asiaticoside Basic information
| Product Name: | Asiaticoside |
| Synonyms: | 2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy;asiaticosid;blastoestimulina;dermatologico;ranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-o-beta-d-glucopyranosylester;CENTELASE;ASIATICOSIDE;MADECASOL |
| CAS: | 16830-15-2 |
| MF: | C48H78O19 |
| MW: | 959.12 |
| EINECS: | 240-851-7 |
| Product Categories: | Inhibitors;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Saponins;Alkaloids;Natural Plant Extract;The group of Asiaticoside |
| Mol File: | 16830-15-2.mol |
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Asiaticoside Chemical Properties
| Melting point | 235-238°C |
| alpha | D20 -14° (alc) |
| Boiling point | 1017.5±65.0 °C(Predicted) |
| density | 1.44±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 160℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly) |
| pka | 12.50±0.70(Predicted) |
| form | Solid |
| color | Crystals |
| Water Solubility | 99mg/L |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | ANTIOXIDANT
SKIN CONDITIONING
PERFUMING |
| InChIKey | WYQVAPGDARQUBT-KRQXBQLUNA-N |
| LogP | 0.44 at 22℃ |
| CAS DataBase Reference | 16830-15-2(CAS DataBase Reference) |
Safety Information
| Safety Statements | 24/25 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | YU9625000 |
| F | 1-10 |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
Asiaticoside Usage And Synthesis
| Description | Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels. |
| Chemical Properties | White powder |
| Uses | wound healing, anxiolytic |
| Uses | Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation. |
| Definition | ChEBI: Asiaticoside is a triterpenoid saponin. |
| Flammability and Explosibility | Not classified |
| Biological Activity | Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model [1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression [2]. |
| Safety Profile | Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds. |
| storage | +4°C |
| References | [1] XINGYING ZHAO, JINGWEN ZHOU*; Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast[J]. ACS Sustainable Chemistry & Engineering, 2024, 12 10: 4028-4040. DOI:10.1021/acssuschemeng.3c07046.
[2] W. H. SURIYAH. In Vitro Wound Healing Effect of Asiaticoside Extracted from Centella asiatica (‘Pegaga’) on Human Gingival Fibroblast Cell Line[J]. Materials Science Forum, 2021, 72 1: 224-229. DOI:10.4028/www.scientific.net/MSF.1025.224.
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Asiaticoside Preparation Products And Raw materials
| Raw materials | PETROLEUM ETHER |
