Introduction：Basic information about AVICULARIN CAS 572-30-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
AVICULARIN Basic information
| Product Name: | AVICULARIN |
| Synonyms: | AVICULARIN;QUERCETIN-3-ARABINOSIDE;Avicularoside;Fenicularin;3-(α-L-Arabinofuranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;Quercetin 3-α-L-arabinofuranoside;Avicularin(Quercetin 3-alpha-L-arabinofuranoside);QUERCETIN-3-ARABINOSIDE hplc |
| CAS: | 572-30-5 |
| MF: | C20H18O11 |
| MW: | 434.35 |
| EINECS: | |
| Product Categories: | Flavanols;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 572-30-5.mol |
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AVICULARIN Chemical Properties
| Melting point | 207-208 °C |
| Boiling point | 855.4±65.0 °C(Predicted) |
| density | 1.86±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly, Sonicated), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 6.17±0.40(Predicted) |
| color | Pale Yellow to Light Yellow |
| Stability: | Hygroscopic |
| Major Application | food and beverages |
| InChI | InChI=1/C20H18O11/c21-8-4-11(24)14-13(5-8)30-18(7-1-2-9(22)10(23)3-7)19(16(14)27)31-20-17(28)15(26)12(25)6-29-20/h1-5,12,15,17,20-26,28H,6H2/t12-,15-,17+,20?/s3 |
| InChIKey | PZZRDJXEMZMZFD-TTYPJOBMNA-N |
| SMILES | C1(OC2=C(C(O)=CC(O)=C2)C(=O)C=1OC1OC[C@H](O)[C@H](O)[C@H]1O)C1C=CC(O)=C(O)C=1 |&1:17,19,21,r| |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
AVICULARIN Usage And Synthesis
| Chemical Properties | Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Saururus chinensis (Lour.) Baill. |
| Uses | Quercetin-3-arabinoside can be used to prevent or treat degenerative brain disease. |
| Definition | ChEBI: A quercetin O-glycoside in which an alpha-L-arabinofuranosyl residue is attached at position 3 of quercetin via a glycosidic linkage. It is isolated particularly from Juglans regia and ital Foeniculum vulgare. |
| in vivo | Avicularin (injected in articular cavity of the knee, 0.5-2 mg/kg, twice a week for 4 weeks) attenuates the development of OA (osteoarthritis) in ACLT-induced rats[4].
?Avicularin (oral administration, 50 and 100 mg/kg, for 21 days) attenuates memory Impairment in rats with amyloid Beta-induced Alzheimer's disease[5].
| Animal Model: | ACLT (anterior cruciate ligament transection)-induced rats[4] | | Dosage: | 0.5, 1, 2 mg/kg | | Administration: | Injected into the articular cavity of the right knee, twice a week for 4 weeks. | | Result: | Alleviated the tibial subchondral osteolysis, reduces bone loss, and increases the bone mass of tibial subchondral bone.
Attenuated ECM degradation, the loss of Aggrecan and Collagen II in ACLT-induced rats.
Decreased the MMP3 and MMP13 protein level.| Animal Model: | Rats with amyloid Beta-induced Alzheimer's disease[5] | | Dosage: | 25, 50, and 100 mg/kg | | Administration: | Oral administration, for 21 days | | Result: | Enhanced cognition activity, and reversed the effects of amyloid beta-induced inflammatory response and excessive oxidative stress. |
| | IC 50 | GLUT4; PPARγ; COX-2 |
AVICULARIN Preparation Products And Raw materials |
