Introduction：Basic information about Benactyzine CAS 302-40-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Benactyzine Basic information
| Product Name: | Benactyzine |
| Synonyms: | 2-diethylaminoethyl 2-hydroxy-2,2-diphenyl-acetate;benactyzine;Benactyzine (base and/or unspecified salts);2-Diethylaminoethyl benzilate;Benzilic acid, 2-(diethylamino)ethyl ester;Diethylaminoethyl benzilate;Benactyzin;Diphenylglycolic acid 2-(diethylamino)ethyl ester |
| CAS: | 302-40-9 |
| MF: | C20H25NO3 |
| MW: | 327.42 |
| EINECS: | 2061238 |
| Product Categories: | |
| Mol File: | 302-40-9.mol |
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Benactyzine Chemical Properties
| Melting point | 51° |
| Boiling point | 465.31°C (rough estimate) |
| density | 1.1392 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | 2-8°C |
| pka | 11.31±0.29(Predicted) |
| NIST Chemistry Reference | Benactyzine(302-40-9) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| Hazardous Substances Data | 302-40-9(Hazardous Substances Data) |
| Toxicity | human,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982. |
Benactyzine Usage And Synthesis
| Originator | Suavitil,Merck Sharp andDohme,US,1957 |
| Definition | ChEBI: 2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester is a diarylmethane. |
| Manufacturing Process | 114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 partof metallic sodium were placed in a flask attached to a total-reflux variabletake-off fractionating column. The pressure was reduced to 100 mm and heatwas applied by an oil bath the temperature of which was slowly raised to90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C).When the distillation of the ethanol became slow, the bath temperature wasraised to 120°C. When the vapor temperature indicated distillation of theamino alcohol the take off valve was closed and the mixture was refluxed forone hour. At the end of this period the vapor temperature had dropped andtwo more parts of ethanol were distilled, The remaining aminoalcohol wasslowly distilled for three hours. The pressure was then reduced to 20 mm andthe remainder of the aminoalcohol distilled at 66°C. During the reaction thecolor of the solution changed from yellow to deep red. The residue wasdissolved in 500 parts of ether, washed once with dilute brine, and three timeswith water, dried over sodium sulfate and finally dried over calcium sulfate.500 parts of a saturated solution of HCl in absolute ether was added and theresulting precipitate filtered. Dry HCl gas was passed into the filtrate to aslight excess and the precipitate again filtered. The combined precipitateswere washed with cold acetone. The 106 parts of product was purified byrecrystallization from acetone as fine white crystals which melt at 177°-178°C. |
| Therapeutic Function | Tranquilizer; Anticholinergic |
Benactyzine Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Sodium-->ETHYL BENZILATE |
| Preparation Products | Methylbenactyzine bromide |
