Introduction：Basic information about BENACTYZINE HYDROCHLORIDE CAS 57-37-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
BENACTYZINE HYDROCHLORIDE Basic information
| Product Name: | BENACTYZINE HYDROCHLORIDE |
| Synonyms: | 2-(diethylamino)-ethanobenzilatehydrochloride;2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid;Benactyzine HCL;BENACTYZINE HYDROCHLORIDE 98+%;BENACTYCIN HYDROCHLORIDE;2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester;Amizyl;2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech] |
| CAS: | 57-37-4 |
| MF: | C20H26ClNO3 |
| MW: | 363.88 |
| EINECS: | 200-324-4 |
| Product Categories: | Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 57-37-4.mol |
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BENACTYZINE HYDROCHLORIDE Chemical Properties
| Melting point | 177-179 °C(lit.) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | Crystals from Me2CO |
| Merck | 14,1029 |
| CAS DataBase Reference | 57-37-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (57-37-4) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DD2800000 |
| TSCA | TSCA listed |
| HS Code | 2922.50.4000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59 |
BENACTYZINE HYDROCHLORIDE Usage And Synthesis
| Originator | Suavitil,Merck Sharp andDohme,US,1957 |
| Uses | Benactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic. |
| Manufacturing Process | 114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 partof metallic sodium were placed in a flask attached to a total-reflux variabletake-off fractionating column. The pressure was reduced to 100 mm and heatwas applied by an oil bath the temperature of which was slowly raised to90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C).When the distillation of the ethanol became slow, the bath temperature wasraised to 120°C. When the vapor temperature indicated distillation of theamino alcohol the take off valve was closed and the mixture was refluxed forone hour. At the end of this period the vapor temperature had dropped andtwo more parts of ethanol were distilled, The remaining aminoalcohol wasslowly distilled for three hours. The pressure was then reduced to 20 mm andthe remainder of the aminoalcohol distilled at 66°C. During the reaction thecolor of the solution changed from yellow to deep red. The residue wasdissolved in 500 parts of ether, washed once with dilute brine, and three timeswith water, dried over sodium sulfate and finally dried over calcium sulfate.500 parts of a saturated solution of HCl in absolute ether was added and theresulting precipitate filtered. Dry HCl gas was passed into the filtrate to aslight excess and the precipitate again filtered. The combined precipitateswere washed with cold acetone. The 106 parts of product was purified byrecrystallization from acetone as fine white crystals which melt at 177°-178°C. |
| Therapeutic Function | Tranquilizer; Anticholinergic |
| Safety Profile | Poison by ingestion,intraperitoneal, subcutaneous, intradermal,and intravenous routes. Human systemiceffects by ingestion of very small amounts:toxic psychosis. Experimental reproductiveeffects. When heated to decomposition itemits very toxic fumes of NO, and HCl |
BENACTYZINE HYDROCHLORIDE Preparation Products And Raw materials
| Raw materials | Ethylamine-->Benzilic acid-->Hydrochloric acid-->Sodium-->ETHYL BENZILATE |
