Introduction：Basic information about Benproperine phosphate CAS 19428-14-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Benproperine phosphate Basic information
| Product Name: | Benproperine phosphate |
| Synonyms: | 1-[2-(2-benzylphenoxy)-1-methylethyl]piperidine phosphate;BENPROPERINE PHOSPHATE;1-(2-Benzylphenoxy)-2-piperidinopropane phosphate;1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine monophosphate;ASA 158-5;Blascorid;Piperidine, 1-[1-methyl-2-[(a-phenyl-o-tolyl)oxy]ethyl]-, phosphate (1:1) (8CI);BENPROPERINE PHOSPHATE CP2000 |
| CAS: | 19428-14-9 |
| MF: | C21H30NO5P |
| MW: | 407.44 |
| EINECS: | 243-050-0 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 19428-14-9.mol |
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Benproperine phosphate Chemical Properties
| Melting point | 150-152° |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C21H27NO.H3O4P/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19;1-5(2,3)4/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3;(H3,1,2,3,4) |
| InChIKey | MCVUURBOSHQXMK-UHFFFAOYSA-N |
| SMILES | C1(C=CC=CC=1OCC(C)N1CCCCC1)CC1=CC=CC=C1.P(=O)(O)(O)O |
| CAS DataBase Reference | 19428-14-9(CAS DataBase Reference) |
Safety Information
| Toxicity | LD50 orally in mice: 1431 mg/kg (Tellini, De Fina) |
Benproperine phosphate Usage And Synthesis
| Chemical Properties | Off-White Solid |
| Uses | An antitussive. |
| in vivo | Benproperine phosphate (50, 100?mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth[1].
?Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1].
| Animal Model: | Female BALB/c nude mice of 6-week-old with AsPC-1 cells[1] | | Dosage: | 50, 100?mg/kg | | Administration: | Oral gavage; 5?days per week for 4?weeks | | Result: | Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change. |
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Benproperine phosphate Preparation Products And Raw materials
