Introduction：Basic information about BETULINIC ACID METHYL ESTER CAS 2259-06-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
BETULINIC ACID METHYL ESTER Basic information
| Product Name: | BETULINIC ACID METHYL ESTER |
| Synonyms: | BETULINIC ACID METHYL ESTER;3B-HYDROXY-LUP-20(29)-EN-28-OIC ACID METHYL ESTER;Lup-20(29)-en-28-oic acid, 3-hydroxy-, methyl ester, (3beta)-;Methylbetulinate;BETULINIC ACID METHYL ESTER hplc;BETULINIC ACID METHYLESTER WITH HPLC;Lup-20(29)-en-28-oic acid, 3-hydroxy-, methyl ester, (3β)-;betulinate, Methyl |
| CAS: | 2259-06-5 |
| MF: | C31H50O3 |
| MW: | 470.73 |
| EINECS: | 218-857-6 |
| Product Categories: | Tri-Terpenoids |
| Mol File: | 2259-06-5.mol |
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BETULINIC ACID METHYL ESTER Chemical Properties
| Melting point | 222-223°C |
| Boiling point | 523.5±33.0 °C(Predicted) |
| density | 1.036±0.06 g/cm3(Predicted) |
| pka | 15.16±0.70(Predicted) |
| form | A solid |
| LogP | 9.400 (est) |
Safety Information
BETULINIC ACID METHYL ESTER Usage And Synthesis
| Description | Betulinic acid methyl ester is a lupane-type triterpenoid and an esterified version of betulinic acid that has been found in Helicteres hirsuta and has diverse biological activities. It inhibits HIV-1 reverse transcriptase (IC50 = 11 μM). Betulinic acid methyl ester is active against L. braziliensis and T. cruzi (IC50s = 69.9 and 93.3 μM, respectively). It induces melanogenesis in (EC50 = 2.5 μM) and inhibits the growth of B16 2F2 melanoma cells in vitro (IC50 = 4.9 μM). Betulinic acid methyl ester is cytotoxic to SK-LU-1, HepG2, HeLa, SK-MEL-2, and AGS cells (IC50s = 60.84, 77.43, 80.17, 66.17, and 69.94 μg/ml, respectively). |
| Uses | Betulinic acid methyl ester, a betulinic acid derivative, possesses antiprotozoal activity[1]. |
| Definition | ChEBI: Betulinic acid methyl ester is a triterpenoid. |
| Biological Activity | Betulinic acid methyl ester is a natural compound extracted from the bark of the birch tree with anti-inflammatory and antiprotozoal activity. Studies have shown it to be a potent inhibitor of cancer cell growth in vitro and in vivo. It has also been shown to have hypoglycaemic effects in mice. |
| References | [1] D B Domínguez-Carmona, et al. Antiprotozoal activity of betulinic acid derivatives. Phytomedicine. 2010 Apr;17(5):379-82. DOI:10.1016/j.phymed.2009.08.002 |
BETULINIC ACID METHYL ESTER Preparation Products And Raw materials
