Bupivacaine hydrochloride CAS 14252-80-3

Introduction：Basic information about Bupivacaine hydrochloride CAS 14252-80-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Bupivacaine hydrochloride Basic information

• Product Name: Bupivacaine hydrochloride
• Synonyms: BUPIVACAINE HYDROCHLORIDE;(+,-)-1-butyl-2’,6’-pipecoloxylididemonohydrochloride,monohydrate;Bupivacaine hydrochloride 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride;Bupivacaine Hydrochloride, USP;IN STOCK BUPIVACAINE HYDROCHLORIDE CAS NO.14252-80-3;BUPIVACAINE HYDROCHLORIDE CAS NO.14252-80-3;Local Anesthetic Pharmaceutical Raw Material Bupivacaine HCl CAS 14252-80-3;1-butyl-2’,6’-pipecoloxylididehydrochloride(+-)
• CAS: 14252-80-3
• MF: C18H28N2O.ClH
• MW: 324.89
• EINECS: 627-065-3
• Product Categories: Sodium channel;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API;TAXOL
• Mol File: 14252-80-3.mol

Bupivacaine hydrochloride Chemical Properties

• Melting point: 249-2510C
• storage temp.: Refrigerator
• solubility: Soluble in water, freely soluble in alcohol.
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic
• InChI: InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H
• InChIKey: SIEYLFHKZGLBNX-UHFFFAOYSA-N
• SMILES: C1(CCCCN1CCCC)C(=O)NC1C(C)=CC=CC=1C.Cl
• CAS DataBase Reference: 14252-80-3(CAS DataBase Reference)

Safety Information

• Hazard Codes: T+
• Risk Statements: 26/27/28
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: TK6125000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2933399090
• Toxicity: LD50 in mice (mg/kg): 7.8 i.v., 82 s.c. (Henn, Brattsand)

Bupivacaine hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Uses

antineoplastic

Uses

Bupivacaine Hydrochloride is the salt form of Bupivacaine (B689561); is a sodium channel blocker, local anesthetic.

Definition

ChEBI: Bupivacaine hydrochloride (anhydrous) is a racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. It has a role as an adrenergic antagonist, an amphiphile, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor and a local anaesthetic. It contains a levobupivacaine hydrochloride (anhydrous), a dextrobupivacaine hydrochloride (anhydrous) and a bupivacaine(1+).

Brand name

Marcaine (Hospira); Sensorcaine(AstraZeneca).

Biological Functions

Bupivacaine hydrochloride (Marcaine, Sensorcaine)has particularly long action, and some nerve blocks lastmore than 24 hours; this is often an advantage for postoperativeanalgesia. Its use for epidural anesthesia inobstetrics has attracted interest because it can relievethe pain of labor at concentrations as low as 0.125%while permitting some motor activity of abdominalmuscles to aid in expelling the fetus. The lower concentrationminimizes the possibility of cardiac toxicity.Fetal drug concentrations remain low, and drug-inducedneurobehavioral changes are not observed in the newborn.Bupivacaine also is approved for spinal anesthesiaand is approximately four times more potent and moretoxic than mepivacaine and lidocaine. It can be usedwith or without epinephrine.

Clinical Use

Bupivacaine hydrochloride injection is a clear, colorless solution intended for use in adults to provide local or regional anesthesia or analgesia. It is suitable for various applications, including surgical procedures, dental and oral surgery, diagnostic and therapeutic interventions, as well as obstetric procedures.