Introduction：Basic information about Carbasalate calcium CAS 5749-67-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Carbasalate calcium Basic information
| Product Name: | Carbasalate calcium |
| Synonyms: | Carbasalate Calium;Carbaspirin calcium;Carbaspirin;Carbasalate calcium;Complex with urea;Carbasalate Calcium 5749-67-7;calcium,2-acetyloxybenzoate,urea;arbasalate calcium |
| CAS: | 5749-67-7 |
| MF: | C10H14CaN2O5 |
| MW: | 282.31 |
| EINECS: | 227-273-0 |
| Product Categories: | veterinary drugs;Pharmaceutical intermediates;5749-67-7 |
| Mol File: | 5749-67-7.mol |
|
Carbasalate calcium Chemical Properties
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Freely soluble in water and in dimethylformamide, practically insoluble in acetone and in anhydrous methanol. |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C9H8O4.CH4N2O.Ca.2H/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;2-1(3)4;;;/h2-5H,1H3,(H,11,12);(H4,2,3,4);;; |
| InChIKey | BMMIBWSFPSYDEH-UHFFFAOYSA-N |
| SMILES | C(=O)(N)N.C(C1C=CC=CC=1OC(=O)C)(=O)O.[Ca] |
| CAS DataBase Reference | 5749-67-7 |
Safety Information
Carbasalate calcium Usage And Synthesis
| Uses | Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug. |
| Description | Carbasalate calcium is a calcium-urea chelate of aspirin that has analgesic, anti-inflammatory, and antipyretic effects. It reduces carrageenan-induced paw edema in rats. |
| Chemical Properties | White or almost white, crystalline powder. |
| Originator | Calurin,Dorsey,US,1959 |
| Uses | Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; antiinflammatory. |
| Uses | Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug. |
| Manufacturing Process | 500 g of finely powdered acetylsalicylic acid and 160 g of calcium carbonate(precipitated chalk), are intimately mixed and 3,000 cc of water are added.The mixture is stirred for 15 minutes or until the reaction is completed, whichis indicated by the cessation of the liberation of carbon dioxide. Thetemperature is desirably maintained below 20°C by any suitable means. Themass is allowed to settle until the supernatant liquor is almost clear; thisusually takes about 5 minutes, and the mixture is then filtered to removeunreacted material. This part of the process is carried out as quickly aspossible so as to minimize any tendency of the calcium aspirin to hydrolyze inthe solution. The filtrate is cooled to about 10°C and 1 to 1.5 volumes of 97% methanol, or pure wood alcohol is added. This causes the calcium aspirin toprecipitate and the mass is then filtered to remove as thoroughly as possiblethe mother liquor. The residue of calcium aspirin is then suspended in aquantity of methanol equivalent to the volume previously used as aprecipitant, and it is allowed to stand there for one hour or more withoccasional or continuous agitation. The mass is again filtered, the filtratebeing employed for the precipitation of calcium aspirin in a later batch. Afterthe filtering of the first wash liquor, the calcium aspirin is again suspended inanother quantity of methanol of an equivalent volume. This constitutes thesecond wash and it is carried out in the same way as the first wash. Thefiltrate is employed as a first wash in a later batch and this filtrate in turn isused, as is the filtrate of the first wash, for the precipitation of more calciumaspirin. Fresh alcohol is used as a new wash in a later batch and the washesare carried out in series. After the second wash the calcium aspirin is dried ina suitable manner, as by passing dry warm air over it, the temperature notbeing allowed to rise to such an extent as to decompose the aspirin;preferably the temperature is not permitted to rise above 50°C, but should behigh enough to avoid deposition of water vapor, and the drying is completedwhen there is no longer an odor of methanol. |
| Therapeutic Function | Analgesic, Antipyretic, Antirheumatic |
| Mechanism of action | Carbasalate calcium is a non-steroidal anti-inflammatory drug. In addition to their anti-inflammatory effects, they are analgesic, antipyretic and platelet inhibitory. They block prostaglandin synthesis by inhibiting the enzyme cyclooxygenase, which converts arachidonic acid into cyclic endoperoxide, the precursor of prostaglandins. Inhibition of prostaglandin synthesis is responsible for their analgesic, antipyretic, and platelet-inhibitory effects; other mechanisms may contribute to their anti-inflammatory effects. |
| References | [1] F E MURRAY. Comparison of effects of calcium carbasalate and aspirin on gastroduodenal mucosal damage in human volunteers.[J]. Gut, 1996, 38 1: 11-14. DOI: 10.1136/gut.38.1.11
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras. |
Carbasalate calcium Preparation Products And Raw materials
| Raw materials | Acetylsalicylic acid-->Calcium carbonate-->Calcium aspirin-->Urea |
