Introduction：Basic information about Carbazochrome CAS 69-81-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Carbazochrome Basic information
| Product Name: | Carbazochrome |
| Synonyms: | CROMADRENAL;CROMOSIL;CARBAZOCHROME;3-HYDROXY-1-METHYL-5,6-INDOLINEDION 5-SEMICARBAZONE;3-hydroxy-1-methyl-5,6-indolinedione 5-semicarbazone;3-HYDROXY-1-METHYL-5,6-INDOLINEDIONE SEMICARBAZONE;ADENOCHROME SEMICARBAZONE;ADRENOXYL |
| CAS: | 69-81-8 |
| MF: | C10H12N4O3 |
| MW: | 236.23 |
| EINECS: | 200-717-0 |
| Product Categories: | 69-81-8 |
| Mol File: | 69-81-8.mol |
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Carbazochrome Chemical Properties
| Melting point | 203° (dec) |
| density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Water (Slightly, Heated) |
| pka | 12.38±0.40(Predicted) |
| form | Solid |
| color | Dark Orange to Very Dark Orange |
| Water Solubility | Water: 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH) |
| Merck | 14,172 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17) |
| InChIKey | XSXCZNVKFKNLPR-UHFFFAOYSA-N |
| SMILES | N(C(N)=O)N=C1C(=O)C=C2C(=C1)C(O)CN2C |
| CAS DataBase Reference | 69-81-8(CAS DataBase Reference) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | NM1925500 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
Carbazochrome Usage And Synthesis
| Originator | Adrenosem,Beecham,US,1953 |
| Uses | Carbazochrome is an oxidation product of Epinephrine [E588580]) that improves microcirculatory tone. Derivatives such as carbazochrome salicylate and carbazochrome sodium sulfonate, are used as hemostats and treatment to prevent dengue shock syndrome, respectively. |
| Definition | ChEBI: Carbazochrome is a member of indoles. It is functionally related to a semicarbazide. |
| Manufacturing Process | A suspension containing 1 part by weight of adrenalin and 2 to 6 parts byweight of silver oxide in 150 to 250 parts by weight of methanol or ethanol isstirred for about 10 minutes. The alcoholic adrenochrome solution obtained isseparated by draining and the filtrate is quickly evaporated to dryness at lowtemperature and in vacuo. The red crystals of adrenochrome obtained aredissolved in 45 to 55 parts by weight of water. To this solution, 2 parts ofsodium acetate dissolved in 2 to 3 parts of water and 2 parts of semicarbazidehydrochloride dissolved in 2 to 3 parts of water are added. The formedprecipitate consisting of red-orange prismatic needles is separated by filtrationand recrystallized from diluted ethanol. There is obtained 0.30 to 0.40 part byweight of adrenochrome monosemicarbazone dihydrate, melting at 203°C withdecomposition. |
| Therapeutic Function | Hemostatic |
Carbazochrome Preparation Products And Raw materials
| Raw materials | potassium ferricyanide-->Adrenalone hydrochloride-->L(-)-Epinephrine-->Semicarbazide hydrochloride-->Silver oxide |
