Introduction：Basic information about Cefaclor monohydrate CAS 70356-03-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cefaclor monohydrate Basic information
| Product Name: | Cefaclor monohydrate |
| Synonyms: | (7R)-3-Chloro-7-[[(R)-aminophenylacetyl]amino]cepham-3-ene-4-carboxylic acid sodium salt;Muco-panoral;(6R,7R)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3-chloro-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;(6R,7R)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate;Cefaclor (400 mg);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-phenylacetyl]aMino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7R)-;CEFACLOR HYDRATE |
| CAS: | 70356-03-5 |
| MF: | C15H16ClN3O5S |
| MW: | 385.82 |
| EINECS: | 641-991-5 |
| Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents |
| Mol File: | 70356-03-5.mol |
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Cefaclor monohydrate Chemical Properties
| Melting point | >180°C (dec.) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Slightly soluble in water, practically insoluble in methanol and in methylene chloride. |
| form | Solid |
| color | White to Light Beige |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/s3 |
| InChIKey | WKJGTOYAEQDNIA-UZPHMIKQNA-N |
| SMILES | O=C1[C@@H](NC(=O)[C@@H](C2C=CC=CC=2)N)[C@@]2([H])SCC(Cl)=C(C(=O)O)N12.O |&1:2,6,14,r| |
| CAS DataBase Reference | 70356-03-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 42/43-36 |
| Safety Statements | 22-36/37-45 |
| WGK Germany | 2 |
| RTECS | XI0363000 |
| HS Code | 2941906000 |
| Storage Class | 11 - Combustible Solids |
Cefaclor monohydrate Usage And Synthesis
| Description | Cefaclor was found by Eli Lilly & Co. in 1976 in the course of studies on the improvement of synthetic procedures for cephalexin. The intermediates with chlorine at the 3 position of the cephem nucleus have excellent antibacterial activity. Cefaclor was selected from among the various derivatives that differed at the 7 position because of its strong activity and high bioavailability following oral administration. |
| Chemical Properties | Crystalline Solid |
| Uses | Antibacterial;Bacterial transpeptidase inhibitor |
| Uses | Second-generation cephalosporin antibiotic. Antibacterial. |
| Brand name | Ceclor (Lilly); Raniclor (Ranbaxy). |
| Contact allergens | Cefaclor is a semisynthetic cephalosporin antibiotic,related to cefalexin, and a frequent inducer of serumsickness-like reactions. |
Cefaclor monohydrate Preparation Products And Raw materials
| Raw materials | Phosphorus pentachloride-->Acetamide-->Phenylacetic acid-->Peroxyacetic acid-->N-Chlorosuccinimide-->Methyl chloroformate-->Ozone-->Penicillin G-->Cefaclor-->trans-Methyl crotonate |
