Cetrimide CAS 8044-71-1

Introduction：Basic information about Cetrimide CAS 8044-71-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Cetrimide Basic information

• Product Name: Cetrimide
• Synonyms: TRIMETHYLMYRISTYLAMMONIUM BROMIDE;TRIMETHYL-TETRADECYLAMMONIUM BROMIDE;TTAB;N-TETRADECYL-N,N,N-TRIMETHYLAMMONIUM BROMIDE;(N-TETRADECYL)TRIMETHYLAMMONIUM BROMIDE;cetavlon;cetraol;lissolaminev
• CAS: 8044-71-1
• MF: C17H38BrN
• MW: 336.39
• EINECS: 617-073-5
• Mol File: 8044-71-1.mol

Cetrimide Chemical Properties

• Melting point: 245-250 °C(lit.)
• solubility: H₂O: 10 % (w/v)
• InChI: InChI=1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
• InChIKey: CXRFDZFCGOPDTD-UHFFFAOYSA-M
• SMILES: [N+](CCCCCCCCCCCCCC)(C)(C)C.[Br-]
• CAS DataBase Reference: 8044-71-1(CAS DataBase Reference)

Safety Information

• Hazard Codes: C
• Risk Statements: 34-20/21/22
• Safety Statements: 26-36/37/39-45-28
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 3
• RTECS: BS5776000
• F: 3
• HS Code: 29181100

Cetrimide Usage And Synthesis

Chemical Properties

White or almost white, voluminous, free-flowing powder.

Chemical Properties

Cetrimide is a white to creamy white, free-flowing powder, with afaint but characteristic odor and a bitter, soapy taste.

Uses

antiinfectives

Production Methods

Cetrimide is prepared by the condensation of suitable alkylbromides and trimethylamine.

Definition

ChEBI: Cetrimide is an organic molecular entity.

Pharmaceutical Applications

Cetrimide is a quaternary ammonium compound that is used incosmetics and pharmaceutical formulations as an antimicrobialpreservative. It may also be used as a cationicsurfactant. In eye-drops, it is used as a preservative at aconcentration of 0.005% w/v.Therapeutically, cetrimide is used in relatively high concentrations,generally as 0.1–1.0% w/v aqueous solutions, cream or sprayas a topical antiseptic for skin, burns, and wounds.(1) Solutionscontaining up to 10% w/v cetrimide are used as shampoos toremove the scales in seborrheic dermatitis.Cetrimide is also used as a cleanser and disinfectant for hardcontact lenses, although it should not be used on soft lenses; as aningredient of cetrimide emulsifying wax, and in o/w creams (e.g.cetrimide cream).

Safety

Most adverse effects reported relate to the therapeutic use ofcetrimide. If ingested orally, cetrimide and other quaternaryammonium compounds can cause nausea, vomiting, muscleparalysis, CNS depression, and hypotension; concentrated solutionsmay cause esophageal damage and necrosis. The fatal oral humandose is estimated to be 1.0–3.0 g.
At the concentrations used topically, solutions do not generallycause irritation, although concentrated solutions have occasionallybeen reported to cause burns. Cases of hypersensitivity have beenreported following repeated application.
Adverse effects that have been reported following irrigation ofhydatid cysts with cetrimide solution include chemical peritonitis, methemoglobinemia with cyanosis, and metabolic disorders.

storage

Cetrimide is chemically stable in the dry state, and also in aqueoussolution at ambient temperatures. Aqueous solutions may besterilized by autoclaving. Water containing metal ions and organicmatter may reduce the antimicrobial activity of cetrimide.
The bulk material should be stored in a well-closed container in acool, dry place.

Incompatibilities

Incompatible with soaps, anionic surfactants, high concentrationsof nonionic surfactants, bentonite, iodine, phenylmercuric nitrate,alkali hydroxides, and acid dyes. Aqueous solutions react withmetals.

Regulatory Status

Included in nonparenteral medicines licensed in the UK. Included inthe Canadian List of Acceptable Non-medicinal Ingredients.
Cetrimide is on the list of ‘Existing Active Substances’ on themarket in the Europe, and is registered according to REACHregulation. Cetrimide is not present in any approved product in theUSA.

Cetrimide Preparation Products And Raw materials

• Raw materials: Trimethylamine