Introduction：Basic information about Cetrorelix CAS 120287-85-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cetrorelix Basic informationDescription
| Product Name: | Cetrorelix |
| Synonyms: | AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH;CETRORELIX;CETRORELIX ACID;CETRIZINEDIHYDROCHLORIDE;N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2;Cetrorelixum;Cetrorelixum [inn-latin];Unii-oon1hfz4ba |
| CAS: | 120287-85-6 |
| MF: | C70H92ClN17O14 |
| MW: | 1431.04 |
| EINECS: | 686-384-6 |
| Product Categories: | Peptide;GYL |
| Mol File: | 120287-85-6.mol |
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Cetrorelix Chemical Properties
| Melting point | >259°C (dec.) |
| density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly, Heated), Methanol (Very Slightly) |
| form | Solid |
| pka | 9.82±0.15(Predicted) |
| color | White to Off-White |
| InChIKey | SBNPWPIBESPSIF-MHWMIDJBSA-N |
Safety Information
| Hazardous Substances Data | 120287-85-6(Hazardous Substances Data) |
Cetrorelix Usage And Synthesis
| Description | Cetrorelix was launched in Germany for the treatment offemale infertility. It is a decapeptidic analog of luteinizing hormone-releasinghormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3,6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelixis an extremely potent and long acting gonadotrophin releasing hormone(GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretionimmediately after administration. Moreover, it has a low histamine-releasingpotency. Cetrorelix will be the first LH-RH antagonist approved worldwide. Inseveral Phase III clinical trials, female patients receiving Cetrorelix had asuccessful controlled ovulation thus avoiding a premature LH-surge. Cetrorelixcould be a first-choice in-vitro fertilization (IVF) treatment without thecomplications of current controlled ovarian hyperstimulation protocols. Cetrorelixis currently under clinical investigation for the treatment of diverse sex hormonedependent disorders such as benign prostate hypertrophy, breast, ovarian orprostate cancers and diverse gynaecological disorders. |
| Originator | Asta Medica (Germany) |
| Uses | Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast. |
| Definition | ChEBI: Cetrorelix is a synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent. |
| Indications | Cetrorelix is used to delay your ovaries from releasing eggs too early (ovulation). It is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian stimulation. |
| Brand name | Cetrotide (Serono). |
| Side effects | Cetrorelix is usually administered by subcutaneous injection. The most common side effects include: pain, itching, swelling, discolouration or redness near the injection site; nausea and headache. Other possible effects may include: abdominal or stomach pain, reduced urine output, diarrhoea, indigestion, weight gain, pelvic pain, etc. Severe allergic reactions are rare. |
| Description | Cetrorelix acetate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. Cetrorelix acetate is an analog of native GnRH with substitutions of amino acids at positions 1, 2, 3, 6, and 10. The molecular formula is C70H92CIN17O14 (Ac-D-Nal1-D-Cpa2-D-Pal3-Ser4-Tyr5- D-Cit6-Leu7-Arg8-Pro9-D -Ala10-NH2), and the molecular weight is 1431 Dalton, calculated as the anhydrous free base. |
Cetrorelix Preparation Products And Raw materials
| Raw materials | Boc-Arg(Tos)-OH-->BOC-L-Proline-->BOC-L-Leucine |
