Chlorodiphenylphosphine CAS 1079-66-9
Introduction：Basic information about Chlorodiphenylphosphine CAS 1079-66-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Chlorodiphenylphosphine Basic information
| Product Name: | Chlorodiphenylphosphine |
| Synonyms: | diphenyl-phosphinouschlorid;Phosphine, chlorodiphenyl-;AURORA KA-1322;Diphenyl phosphine chloride;DIPHENYLPHOSPHINOUS CHLORIDE;DIPHENYLCHLOROPHOSPHINE;DPPC;CHLORODIPHENYLPHOSPHINE |
| CAS: | 1079-66-9 |
| MF: | C12H10ClP |
| MW: | 220.63 |
| EINECS: | 214-093-2 |
| Product Categories: | Ligand;organophosphine halide;Achiral Phosphine;Aryl Phosphine;P-Cl;Phosphines;Pharmaceutical Intermediates;Chlorophosphines;1079-66-9 |
| Mol File: | 1079-66-9.mol |
Chlorodiphenylphosphine Chemical Properties
| Melting point | 14-16°C |
| Boiling point | 320 °C(lit.) |
| density | 1.229 g/mL at 25 °C(lit.) |
| vapor density | 7.8 (vs air) |
| vapor pressure | 1.3 hPa (20 °C) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Miscible with alcohol. Slightly miscible with ammonia. |
| form | Liquid |
| color | Colorless to yellow |
| Specific Gravity | 1.229 |
| Water Solubility | Reacts violently |
| Sensitive | Air & Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 512032 |
| InChI | 1S/C12H10ClP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H |
| InChIKey | XGRJZXREYAXTGV-UHFFFAOYSA-N |
| SMILES | ClP(c1ccccc1)c2ccccc2 |
| LogP | 5.330 (est) |
| CAS DataBase Reference | 1079-66-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Chlorodiphenylphosphine(1079-66-9) |
| EPA Substance Registry System | Phosphinous chloride, diphenyl- (1079-66-9) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 14-34-29-36 |
| Safety Statements | 26-36/37/39-45-8-30-25-27 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 2 |
| F | 1-9-19 |
| Autoignition Temperature | 320 °C |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29310095 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Met. Corr. 1 Skin Corr. 1B |
| Toxicity | LD50 orally in Rabbit: 316 mg/kg |
| Chemical Properties | Colorless to light yellow liqui |
| Uses | Chlorodiphenylphosphine is used to introduce the diphenylphosphinyl moiety by aryl ortho-lithiation. It is also used as an intermediate to make antioxidants, flame retardants, stabilizers, catalysts, photoinitiators, and optical brighteners. Used as a halogenation reagent for the conversion of alcohols into halides, in the preparation of solid-phase reagent for the conversion of alcohols to alkyl halides. |
| Production Methods | The specific synthesis steps of Chlorodiphenylphosphine are as follows: In a sealed NMR tube filled with argon,Dissolve Ph2P (O) H (0.05 mmol) in 0.5 mL of tetrahydrofuran,Add acetyl chloride (the amount of acetyl chloride added is 1.2 times the equivalent of Ph2P (O) H),The mixture was reacted at 100 ° C for 12 hours with a yield of 99%. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 77, p. 3526, 1955 DOI: 10.1021/ja01618a030 |
| Flammability and Explosibility | Non flammable |
| reaction suitability | reaction type: Buchwald-Hartwig Cross Coupling Reaction reaction type: Heck Reaction reaction type: Hiyama Coupling reaction type: Negishi Coupling reaction type: Sonogashira Coupling reaction type: Stille Coupling reaction type: Suzuki-Miyaura Coupling reagent type: ligand |
| Purification Methods | This air-sensitive, pale yellow lachrymatory liquid is purified by careful fractional distillation and discarding the lower boiling fraction which contains the main impurity PhPCl2 (b 48-51o/0.7mm), and checking for impurities by NMR. [Weinberg J Org Chem 40 3586 1975, Honer et al. Chem Ber 94 2122 1961, Beilstein 16 IV 969.] |
Chlorodiphenylphosphine Preparation Products And Raw materials
| Preparation Products | Diphenylphosphine-->1,1'-Bis(diphenylphosphino)ferrocene-->4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene-->(R)-1-[(1S)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-TERT-BUTYLPHOSPHINE-->4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE-->Vanadium(III) chloride-->(OXYDI-2,1-PHENYLENE)BIS(DIPHENYLPHOSPHINE)-->1-DIPHENYLPHOSPHINO-1'-(DI-TERT-BUTYLPH&-->Phosphine, 4-dibenzofuranyldiphenyl--->2-(Diphenylphosphino)-biphenyl-->2-Diphenylphosphinobenzaldehyde-->DIPHENYL(P-VINYLPHENYL)PHOSPHINE-->4,6-Bis(diphenylphosphino) dibenzofuran, 98%-->1,1-BIS(DIPHENYLPHOSPHINO)ETHYLENE-->Bis[(2-diphenylphosphino)ethyl]ammonium chloride, min. 97%-->(DIPHENYLPHOSPHORYL)METHANOL |
