Chlorotripyrrolidinophosphonium hexafluorophosphate CAS 133894-48-1

Introduction：Basic information about Chlorotripyrrolidinophosphonium hexafluorophosphate CAS 133894-48-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Chlorotripyrrolidinophosphonium hexafluorophosphate Basic information

• Product Name: Chlorotripyrrolidinophosphonium hexafluorophosphate
• Synonyms: PyClOP,ChlorotripyrrolidinophosphoniuMhexafluorophosphat;chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V);Chlorotripyrrolidinophosphonium hexafluorophosphate98+%;Chlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphate;PYCLOP;CHLOROTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE;Chlorotripyrrolidinophosphoniumhexafluorophosphat;PYCLOP CHLOROTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE
• CAS: 133894-48-1
• MF: C12H24ClF6N3P2
• MW: 421.73
• EINECS: 628-539-2
• Mol File: 133894-48-1.mol

Chlorotripyrrolidinophosphonium hexafluorophosphate Chemical Properties

• Melting point: 145-148°C
• storage temp.: 2-8°C
• solubility: soluble in Chloroform, Methanol
• form: Crystalline Powder
• color: White to yellow
• Sensitive: Moisture Sensitive
• BRN: 6842341
• Major Application: peptide synthesis
• InChI: InChI=1S/C12H24ClN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
• InChIKey: BSCYRXJVGSZNKX-UHFFFAOYSA-N
• SMILES: [P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)Cl
• CAS DataBase Reference: 133894-48-1(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xi,C
• Risk Statements: 36/37/38-34
• Safety Statements: 26-36-45-36/37/39
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• F: 10-21
• HazardClass: 8
• PackingGroup: II
• HS Code: 29339900
• Storage Class: 8A - Combustible corrosive hazardous materials

Chlorotripyrrolidinophosphonium hexafluorophosphate Usage And Synthesis

Uses

Crystalline reagent for peptide coupling of a-alkylated N-Fmoc and N-Z-amino acids in high yield and without racemization.

Uses

Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands

Preparation

Preparation of chlorotripyrrolidinophosphonium hexafluorophosphate: addition of chlorine to a diethyl ether solution of tripyrrolidinophosphine, then addition of KPF6 in water. Addition of tripyrrolidinophosphine oxide to a DCM solution of phosphoryl trichloride, then addition of KPF6 in water.

reaction suitability

reaction type: Coupling Reactions