Chonglou Saponin VII CAS 68124-04-9

Introduction：Basic information about Chonglou Saponin VII CAS 68124-04-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Chonglou Saponin VII Basic information

• Product Name: Chonglou Saponin VII
• Synonyms: Chonglou Saponin VII;Paris VII;Chonglouoside Ⅶ;Paris saponin VII;Dioscinin;Chonglou saponin Ⅶ;β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-;Polyphyllin VIT
• CAS: 68124-04-9
• MF: C51H82O21
• MW: 1031.2
• Mol File: 68124-04-9.mol

Chonglou Saponin VII Chemical Properties

• Melting point: 243-245 °C (decomp)
• density: 1.45±0.1 g/cm3(Predicted)
• storage temp.: -20°C, protect from light
• solubility: Soluble in methanol;
• pka: 12?+-.0.70(Predicted)
• form: powder
• color: White
• Water Solubility: sparingly soluble in water
• Major Application: food and beverages
• InChIKey: FBFJAXUYHGSVFN-IYUYFXHASA-N

Safety Information

• WGK Germany: WGK 3
• HS Code: 29329990
• Storage Class: 11 - Combustible Solids

Chonglou Saponin VII Usage And Synthesis

Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Uses	Used for content determination/identification/pharmacological experiments, etc.
Biological Activity	Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research.
Pharmacology	Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on.
in vitro	Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase.
in vivo	Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.
target	Akt p38 Bcl-2 Caspase-9 Caspase-3 PARP-1