Introduction：Basic information about Cytidine 5'-monophosphate disodium salt CAS 6757-06-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cytidine 5'-monophosphate disodium salt Basic information
| Product Name: | Cytidine 5'-monophosphate disodium salt |
| Synonyms: | 5'-CMP 2NA;5'-CYTIDYLIC ACID DISODIUM SALT;CYTIDYLIC ACID DISODIUM SALT;CYTIDINE-5'-MONOPHOSPHATE SODIUM SALT;CYTIDINE-5'-MONOPHOSPHATE DISODIUM SALT;CYTIDINE 5'-PHOSPHATE, SODIUM SALT;CYTIDINE-5'-MONOPHOSPHORIC ACID, DISODIUM;CMP, NA2 |
| CAS: | 6757-06-8 |
| MF: | C9H12N3Na2O8P |
| MW: | 367.16 |
| EINECS: | 229-819-3 |
| Product Categories: | Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;Nucleic acids;Amino Acids;Pharmaceutical;Nucleotide |
| Mol File: | 6757-06-8.mol |
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Cytidine 5'-monophosphate disodium salt Chemical Properties
| Melting point | 300 °C |
| refractive index | 8 ° (C=2, H2O) |
| storage temp. | 2-8°C |
| solubility | water: 100 mg/mL, clear to very slightly hazy, colorless to very faintly yellow |
| form | crystalline |
| color | White |
| biological source | synthetic |
| Water Solubility | water: 100mg/mL, clear to very slightly hazy, colorless to very faintly yellow |
| Cosmetics Ingredients Functions | HAIR CONDITIONING
SKIN CONDITIONING - MISCELLANEOUS |
| InChI | InChI=1/C9H14N3O8P.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3 |
| InChIKey | RCIPNLSOCXMZDD-RFFBCSJBNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,11,r| |
| CAS DataBase Reference | 6757-06-8(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-37/39-36-26 |
| WGK Germany | 3 |
| F | 1-10 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
Cytidine 5'-monophosphate disodium salt Usage And Synthesis
| Uses | Cytidine 5'-Monophosphate Disodium Salt is a salt form of Cytidine 5'-Monophosphate, a constituent of nucleic acids that has been isolated from yeast nucleic acid. |
| Description | Cytidine 5'-monophosphate disodium salt (5'-CMPNa2) is an organic sodium salt that can be used as a pharmaceutical active ingredient. 5'-CMPNa2 can be used with UMP-Na2, vitamin B6, lipoic acid, and magnesium lactate dihydrate to prepare a capsule-type compound drug for the treatment of polyneuropathy[1]. |
| Chemical Properties | White crystalline powder |
| Uses | Cytidine 5′-monophosphate disodium salt has been used:
- in nucleotide stock solution
- as an ectonucleotidase (ENTase) inhibitor to probe 5′-ENTase activity in cortical neurons
- in in vitro studies to estimate its effect on growth response of selected bacteria strains that dominate the piglets′ small intestine
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| Production Methods | The production method of Cytidine 5'-monophosphate disodium salt comprises the following steps: a. adding cytidine, triethyl phosphate and pyridine into a reaction container respectively, and adjusting the reaction temperature to -15-5°C after mixing evenly, and slowly adding a certain amount of phosphorus oxychloride under the temperature condition, and continuing to stir and react for 10-30h after adding; b. taking samples for HPLC analysis, and when the conversion rate is ≥99%, adding 10-15% ice salt water for hydrolysis, and the hydrolysis temperature is controlled to be 0-5°C, and the hydrolysis time is 10-20h; c. after the hydrolysis is completed, standing and stratifying, removing the organic phase, and obtaining a water layer for standby use; d. adjusting the pH of the water layer to 7.0-8.0 with 30% sodium hydroxide, and then dripping 95% alcohol twice the volume of the solution, precipitating crystals, and filtering to obtain a crude product. e. dissolving the crude product, adding activated carbon for decolorization, and continuing to drip 95% alcohol twice the volume of the solution to precipitate crystals, filtering, rinsing, and drying to obtain the finished product Cytidine 5'-monophosphate disodium salt. |
| Definition | ChEBI: Disodium cytidine 5'-monophosphate is an organic sodium salt that is the disodium salt of CMP. It has a role as a human metabolite. It contains a cytidine 5'-monophosphate(2-). |
| Biochem/physiol Actions | Cytidine monophosphate?(CMP) serve as a nucleotide?carrier for sugars. |
| References | [1] M. ALMAKAIEV L. S O Bashura. The risk assessment of the combined medicine in the capsule dosage form at the pharmaceutical development stage[J]. News of Pharmacy, 2021. DOI:10.24959/nphj.21.54. |
Cytidine 5'-monophosphate disodium salt Preparation Products And Raw materials
| Raw materials | Ribonucleic acid |
