Introduction：Basic information about D(-)-Glutamic acid CAS 6893-26-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
D(-)-Glutamic acid Basic information
| Product Name: | D(-)-Glutamic acid |
| Synonyms: | (2R)-2-Aminoglutaric acid;D-α-AMinoglutaric acid;D-1-AMinopropane-1,3-dicarboxylic acid;D(-)-GlutaMic acid, 99+% 25GR;D(-)-GlutaMic acid, 99+% 5GR;(2R)-GlutaMic Acid;NSC 77686;D-Glutaminic acid |
| CAS: | 6893-26-1 |
| MF: | C5H9NO4 |
| MW: | 147.13 |
| EINECS: | 230-000-8 |
| Product Categories: | amino acid;Glutamate receptor;Amino ACIDS SERIES;Glutamic acid [Glu, E];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Nutritional Supplements;Amino Acids |
| Mol File: | 6893-26-1.mol |
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D(-)-Glutamic acid Chemical Properties
| Melting point | 200-202 °C (subl.)(lit.) |
| alpha | -31.3 º (c=10, 2 N HCl) |
| Boiling point | 267.21°C (rough estimate) |
| density | 1.5380 |
| refractive index | 1.4210 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Water (Slightly) |
| pka | pK1:2.162(＋1);pK2:4.272(0);pK3:9.358(－1) (25°C) |
| form | Powder |
| color | White to off-white |
| Water Solubility | 7 g/L (20 ºC) |
| Merck | 14,4469 |
| BRN | 1723800 |
| InChI | 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 |
| InChIKey | WHUUTDBJXJRKMK-GSVOUGTGSA-N |
| SMILES | N[C@H](CCC(O)=O)C(O)=O |
| LogP | -0.969 (est) |
| CAS DataBase Reference | 6893-26-1(CAS DataBase Reference) |
| NIST Chemistry Reference | D-Glutamic acid(6893-26-1) |
| EPA Substance Registry System | D-Glutamic acid (6893-26-1) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| F | 10 |
| TSCA | TSCA listed |
| HS Code | 29224200 |
| Storage Class | 11 - Combustible Solids |
D(-)-Glutamic acid Usage And Synthesis
| Chemical Properties | White cryst. powder |
| Uses | D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism. |
| Uses | D-Glutamic acid acts as a superior to alpha ketoglutarate. It helps in the growth of Lactobacillus arabinosus. It can inhibit the IgE binding to peanut allergens. It is widely used in pharmaceuticals and foods. |
| Uses | D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors. |
| Definition | ChEBI: An optically active form of glutamic acid having D-configuration. |
| General Description | D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan. |
| Biological Activity | Excitatory amino acid acting at NMDA receptors; less active than the L-isomer. |
| Biochem/physiol Actions | Unnatural isomer of glutamic acid. |
| storage | Room temperature |
D(-)-Glutamic acid Preparation Products And Raw materials
| Raw materials | DL-Glutamic acid-->4-methylsulfanyl-2-oxo-butanoic acid-->3-(4-Imidazolyl)-2-oxopropionic acid-->D-Norleucine-->D(-)-Norvaline-->D-Histidine-->D-Glutamine-->D-Methionine-->2-Oxopentanoic acid-->3-METHYL-2-OXOBUTYRIC ACIDDISCONTINUED-->2-oxohexanoic acid-->D-Threonine-->L-Glutamic acid |
| Preparation Products | 5-Hydroxymethylpyrrolidin-2-one-->D-Pyroglutamic acid-->2-Oxobutyric acid-->4-Methyl-2-oxovaleric acid-->2-Ketoglutaric acid-->L-Leucine |
