D-(+)-Maltose monohydrate CAS 6363-53-7
Introduction：Basic information about D-(+)-Maltose monohydrate CAS 6363-53-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
D-(+)-Maltose monohydrate Basic information
| Product Name: | D-(+)-Maltose monohydrate |
| Synonyms: | D-MALTOSE;D-MALTOSE, H2 O;D-(+)-MALTOSE HYDRATE;D(+)-MALTOSE MONOHYDRATE;D-MALTOSE MONOHYDRATE;D-MALATOSE;MALTOBIOSE;MALTOBIOSE MONOHYDRATE |
| CAS: | 6363-53-7 |
| MF: | C12H24O12 |
| MW: | 360.31 |
| EINECS: | 613-294-6 |
| Product Categories: | carbohydrate;Inhibitors;Carbohydrates & Derivatives;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Disaccharides;Sugars;Glycon Biochem |
| Mol File: | 6363-53-7.mol |
D-(+)-Maltose monohydrate Chemical Properties
| Melting point | 119-121 °C (dec.)(lit.) |
| alpha | 137 º (c=4, H2O, NH3) |
| bulk density | 320kg/m3 |
| storage temp. | room temp |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | White |
| PH | 5.0-7.0 (25℃, 0.5M in H2O) |
| Optical Rotation | [α]20/D +130±2°, 24 hr, c = 4% in H2O |
| biological source | potato (tuber) |
| Water Solubility | 1080 g/L (20 ºc) |
| λmax | λ: 260 nm Amax: 0.08 λ: 280 nm Amax: 0.07 |
| Merck | 14,5714 |
| BRN | 5784659 |
| InChI | 1S/C12H22O11.H2O/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12;/h1,4-12,14-21H,2-3H2;1H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+;/m0./s1 |
| InChIKey | HBDJFVFTHLOSDW-DNDLZOGFSA-N |
| SMILES | O.OC[C@@H](O)[C@@H](O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C=O |
| CAS DataBase Reference | 6363-53-7(CAS DataBase Reference) |
| NIST Chemistry Reference | «beta»-Maltose monohydrate(6363-53-7) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 33-63-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| RTECS | OO5250000 |
| F | 3 |
| TSCA | Yes |
| HS Code | 17029010 |
| Storage Class | 13 - Non Combustible Solids |
| Chemical Properties | White crystalline powder |
| Chemical Properties | Maltose occurs as white crystals or as a crystalline powder. It isodorless and has a sweet taste approximately 30% that of sucrose. |
| Uses | A disaccharide commonly found in foods and commonly utilized in brewing processes. |
| Uses | D-(+)-Maltose monohydrate, is commonly found in foods and commonly utilized in brewing processes. It is also used in various culture media in the cell and tissue culture applications. D-(+)-Maltose Monohydrate is used as a substrate for α-glucosidase. It is also used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems. |
| Uses | D-Maltose, an α(1→4) linked disaccharide of D-glucose, is used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems. |
| Production Methods | Maltose monohydrate is prepared by the enzymatic degradation ofstarch. |
| General Description | Maltose monohydrate is commonly used as a tablet filler or excipient in pharmaceutical industry. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Pharmaceutical Applications | Maltose is a disaccharide carbohydrate widely used in foods andpharmaceuticals. In parenteral products, maltose may be used as asource of sugar, particularly for diabetic patients. Crystalline maltose is used as a direct-compression tabletexcipient in chewable and nonchewable tablets. |
| Biochem/physiol Actions | Maltose is a disaccharide containing two glucose molecules with an α(1→4) glycosidic linkage. Maltose can be derived from starch in food through the action of amylase. Maltose can be found in many food products, including beer, cereals, and pasta. |
| Safety | Maltose is used in oral and parenteral pharmaceutical formulationsand is generally regarded as an essentially nontoxic and nonirritantmaterial. However, there has been a single report of a livertransplantation patient with renal failure who developed hyponatremiafollowing intravenous infusion of normal immunoglobulinin 10% maltose. The effect, which recurred on each of foursuccessive infusions, resembled that of hyperglycemia and wasthought to be due to accumulation of maltose and other osmoticallyactive metabolites in the extracellular fluid. LD50 (mouse, IV): 26.8 g/kg LD50 (mouse, SC): 38.6 g/kg LD50 (rabbit, IV): 25.2 g/kg LD50 (rat, IP): 30.6 g/kg LD50 (rat, IV): 15.3 g/kg LD50 (rat, oral): 34.8 g/kg |
| storage | Maltose should be stored in a well-closed container in a cool, dryplace. |
| Purification Methods | Purify maltose by chromatography from aqueous solution on to a charcoal/Celite (1:1) column, wash it with water to remove glucose and other monosaccharides, then elute it with aqueous 75% EtOH. Crystallise it from water, aqueous EtOH or EtOH containing 1% nitric acid. Dry it as the monohydrate at room temperature under vacuum over H2SO4 or P2O5. Also purify it by dissolving it in MeOH, evaporating to a syrup which on standing for 12hours in contact with 1/10th its volume of H2O gives crystals of the monohydrate. Its iodine number is 55.5. The osazone has m 200o(dec) and [] D 20 +58o (c 1.4, H2O). [Howarth et al. J Chem Soc 793 1937, Beilstein 17 III/IV 3057, 17 V 189.] |
| Incompatibilities | Maltose may react with oxidizing agents. A Maillard-type reactionmay occur between maltose and compounds with a primary aminegroup, e.g. glycine, to form brown-colored products. |
| Regulatory Status | In the USA, maltose is considered as a food by the FDA and istherefore not subject to food additive and GRAS regulations.Included in the FDA Inactive Ingredients Database (oral solutions).Included in the Canadian List of Acceptable Non-medicinalIngredients. Included in parenteral products available in a numberof countries worldwide. |
D-(+)-Maltose monohydrate Preparation Products And Raw materials
| Raw materials | Dextrin-->Maltose-->β-Amylase-->LIQUID GLUCOSE |
| Preparation Products | 3-Methyl-1-butanol-->CARAMEL-->Monosodium glutamate-->L-(+)Sodium glutamate-->POLYOXIN A-->POLYOXIN B-->Gongzhulingmeisu-->IMP-->Pullulan |
