Introduction：Basic information about DEXBROMPHENIRAMINE CAS 132-21-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
DEXBROMPHENIRAMINE Basic information
| Product Name: | DEXBROMPHENIRAMINE |
| Synonyms: | (S)-Brompheniramine;(S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine;Disomer;d-Parabromdylamine;(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine;(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;[(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine;DEXBROMPHENIRAMINE |
| CAS: | 132-21-8 |
| MF: | C16H19BrN2 |
| MW: | 319.24 |
| EINECS: | 205-053-5 |
| Product Categories: | |
| Mol File: | 132-21-8.mol |
|
DEXBROMPHENIRAMINE Chemical Properties
| alpha | D25 +42.7° (c = 1 in DMF) |
| form | Oil |
| pka | pKa 9.3 (Uncertain) |
| color | Light brown to brown |
Safety Information
DEXBROMPHENIRAMINE Usage And Synthesis
| Originator | Disomer,White,US,1959 |
| Uses | Antihistaminic. |
| Definition | ChEBI: The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis nd conjunctivitis. |
| Manufacturing Process | The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3-(2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept atroom temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solventusing 5 ml there of per gram of solid. Three subsequent crystallizations from80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% indimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, isobtained from this salt with diethyl ether and aqueous potassium carbonate;[α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is thenreacted with maleic acid. |
| Brand name | Disomer (Schering). |
| Therapeutic Function | Antihistaminic |
DEXBROMPHENIRAMINE Preparation Products And Raw materials
| Raw materials | Maleic acid-->Potassium carbonate |
