Diatrizoate sodium CAS 737-31-5
Introduction：Basic information about Diatrizoate sodium CAS 737-31-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Diatrizoate sodium Basic informationDescription References
| Product Name: | Diatrizoate sodium |
| Synonyms: | 3,5-DIACETAMIDO-2,4,6-TRIIODOBENZOIC ACID SODIUM SALT;3,5-BIS[ACETYLAMINO]-2,4,6-TRIIODOBENZOIC ACID, SODIUM;DIATRIZOIC ACID SODIUM SALT;DIATRIZOATE SODIUM;HYPAQUE SODIUM;LABOTEST-BB LT00455174;SODIUM DIATRIZOATE;Sodium amidotrizoate |
| CAS: | 737-31-5 |
| MF: | C11H8I3N2NaO4 |
| MW: | 635.9 |
| EINECS: | 212-004-1 |
| Product Categories: | Organics;737-31-5 |
| Mol File: | 737-31-5.mol |
Diatrizoate sodium Chemical Properties
| Melting point | 261-262° (dec) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 0.35 g/mL, slightly turbid, colorless |
| form | White Powder |
| color | White to off-white |
| Water Solubility | H2O: 350mg/mL, clear to slightly hazy |
| BRN | 4082984 |
| Major Application | diagnostic assay manufacturing hematology histology |
| InChI | InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1 |
| InChIKey | ZEYOIOAKZLALAP-UHFFFAOYSA-M |
| SMILES | C1(NC(=O)C)C(I)=C(C(I)=C(C([O-])=O)C=1I)NC(=O)C.[Na+] |
| CAS DataBase Reference | 737-31-5(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (737-31-5) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | DG6125000 |
| F | 8-10 |
| HS Code | 29242100 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Resp. Sens. 1 Skin Sens. 1 |
| Hazardous Substances Data | 737-31-5(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in rats: 14.7 g/kg (Langecker) |
| Description | Diatrizoate sodium is a contrast agent used during the X-rays test. It can be used as a diagnostic aid agent during angiography, urography and radiography. It can be applied during visualizing veins, the urinary system, gastrointestinal tract, spleen and joints as well as during the computer tomography (CT scan). It is used in cases where barium is not suitable for application such as patient being allergic to barium. |
| References | https://en.wikipedia.org/wiki/Diatrizoate https://pubchem.ncbi.nlm.nih.gov/compound/Diatrizoate_sodium |
| Chemical Properties | Diatrizoate sodium is a white or almost white powder that has no odor and a slightly salty taste. It dissolves easily in water but only slightly dissolves in ethanol, and it does not dissolve in ether. A 50% aqueous solution has a pH between 6.5 and 8.0. The substance has an iodine content of approximately 59.9%. |
| Originator | Hypaque Sodium,Winthrop,US,1955 |
| Uses | Diatrizoate Sodium is an iodinated radiopaque X-ray contrast medium used in radiology for diagnostic purposes. It is also used as a density gradient reagent to separate blood cells. |
| Definition | ChEBI: Sodium amidotrizoate is the sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. It has a role as a radioopaque medium. It is an organoiodine compound and an organic sodium salt. It contains an amidotrizoic acid anion. |
| Manufacturing Process | 3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount ofsodium hydroxide solution, and the solution was diluted to 310 ml with water.The solution was refluxed with Raney nickel for fifteen minutes, filtered, andthe filtrate was hydrogenated at elevated pressure using platinum oxidecatalyst. After the amount of hydrogen calculated to reduce both nitro groupshad been absorbed, the mixture was filtered, and the filtrate was acidifiedwith an equal volume of concentrated hydrochloric acid. Iodine monochloride(17 ml) in 100 ml of 6N HCl was then added with stirring. The reactionmixture was allowed to stand for two and one-half hours at roomtemperature, then diluted with an equal amount of water with vigorousstirring, and the solid material was collected by filtration and recrystallized from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid,MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5drops of 70% perchloric acid, and the mixture was heated on a steam bath forthree and one-half hours. The reaction mixture was poured into 300 ml of icewater, and then heated on a steam bath until crystallization took place. Thesolid material was collected by filtration, dissolvedin dilute sodium hydroxidesolution, filtered, and hydrochloric acid was added to the filtrate toreprecipitate the acid product. The latter was again dissolved in sodiumhydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6-triiodobenzoic acid, MP above 250°C. The acid may be used as the sodium salt or as the meglumate. |
| Brand name | Md (Mallinckrodt); Urovist Sodium (Berlex). |
| Therapeutic Function | Diagnostic aid (radiopaque medium) |
| Mode of action | The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas. |
Diatrizoate sodium Preparation Products And Raw materials
| Raw materials | Iodine monochloride-->Sodium hydroxide-->Hydrogen-->2-Chloro-3,5-dinitrobenzoic acid-->DIATRIZOIC ACID-->Benzoic acid-->Acetic anhydride |
