Diclazuril CAS 101831-37-2

Introduction：Basic information about Diclazuril CAS 101831-37-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Diclazuril Basic information

• Product Name: Diclazuril
• Synonyms: 2,6-Dichloro-a-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile;Nuoqiu;Vecoxan;2-[3,5-Dichloro-4-(α-cyano-4-chlorobenzyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione;2-[4-(4-Chloro-α-cyanobenzyl)-3,5-dichlorophenyl]-1,2,4-triazine-3,5(2H,4H)-dione;CLINACOX;DICLAZURIL;DICLAZUTIL
• CAS: 101831-37-2
• MF: C17H9Cl3N4O2
• MW: 407.64
• EINECS: 1806241-263-5
• Product Categories: Pharmaceuticals;Aromatics;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Veterinaries;101831-37-2
• Mol File: 101831-37-2.mol

Diclazuril Chemical Properties

• Melting point: 290.5°
• density: 1.56±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
• pka: 5.89±0.20(Predicted)
• form: Solid
• color: White to Light yellow to Light orange
• Merck: 14,3080
• Major Application: forensics and toxicology pharmaceutical (small molecule)
• InChI: InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
• InChIKey: ZSZFUDFOPOMEET-UHFFFAOYSA-N
• SMILES: C1(C=C(C(C(C#N)C2=CC=C(Cl)C=C2)=C(Cl)C=1)Cl)N1N=CC(=O)NC1=O
• LogP: 2.439 (est)
• CAS DataBase Reference: 101831-37-2(CAS DataBase Reference)

Safety Information

• Safety Statements: 24/25
• WGK Germany: 2
• RTECS: CY1697600
• HS Code: 29336990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Repr. 2 STOT RE 2

Diclazuril Usage And Synthesis

Description

Diclazuril (molecular formula: C17H9Cl3N4O2, Trade name: Vecoxan) belongs to a kind of coccidiostat and potent antiprotozoal agents. It is mainly used for the treatment, control, prevention and improvements of Coccidal infections. It alleviates the symptoms of the patients by interrupting the life cycle of the parasites. It induces the morphological changes and attenuates the mitochondrial transmembrane potential in meroites. It can prevent congenital toxoplasmosis and have anticoccidial effects in vivo. It is active through oral administration.  

References

http://www.tabletwise.com/medicine/diclazuril
https://en.wikipedia.org/wiki/Diclazuril
http://www.abcam.com/diclazuril-ab143604.html

Chemical Properties

Light yellow or off-white powder, almost insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methylformamide (DMF), dimethylsulfone (DMSO), tetrahydrofuran (THF).

Uses

Diclazuril is a triazinone antiprotozoal that Nucleotide analog with broad-spectrum anticoccidial activity. It has a control effect on a variety of coccidiosis, and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits.

Definition

ChEBI: 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile is a nitrile.

Application

Diclazuril is a less toxic, orally administered triazine antiprotozoal. It is widely used in veterinary medicine as a feed additive and veterinary drug. It is registered for oral use in broilers and lambs. Its use in cats (one dose of 25 mg/kg BW) is off-label only. It may be used clinically for the treatment of bovine protozoa. It is also used for the treatment of equine protozoan spinal cord encephalitis (EPM) caused by neuronal sarcocysts.

Veterinary Drugs and Treatments

Diclazuril is a coccidiostat. It is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona and as a coccidiostat in broiler chickens. Diclazuril could potentially be useful in treating coccidiosis, Neospora caninum and Toxoplasma infections in dogs or cats.