Introduction：Basic information about Dideoxyadenosine CAS 4097-22-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dideoxyadenosine Basic information
| Product Name: | Dideoxyadenosine |
| Synonyms: | [(2S,5R)-5-(6-Aminopurin-9-yl)oxolan-2-yl]methanol;NSC 98700;Didanosine Related CoMpound B;2',3'-DIDEOXYADENOSINE extapure;2’,3’-dideoxy-adenosin;2',3'-Dideoxy-D-adenosine;9-(2,3-Dideoxy-beta-D-ribofuranosyl)adenine;Didanosine Impurity 7（Didanosine EP Impurity G） |
| CAS: | 4097-22-7 |
| MF: | C10H13N5O2 |
| MW: | 235.24 |
| EINECS: | 223-853-2 |
| Product Categories: | Carbohydrates & Derivatives;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Isotope Labelled Compounds;Bases & Related Reagents;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleosides-Dideoxy Nucleosides |
| Mol File: | 4097-22-7.mol |
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Dideoxyadenosine Chemical Properties
| Melting point | 181-184 °C(lit.) |
| alpha | D25 -25.2° (c = 1.01 in water) |
| Boiling point | 377.64°C (rough estimate) |
| density | 1.2455 (rough estimate) |
| refractive index | -34 ° (C=1, H2O) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/mL; DMSO: 2 mg/mL; Ethanol: Slightly soluble |
| pka | pKa 3.84(H2O t=25.0±0. I=0.01) (Uncertain) |
| form | Powder |
| color | White to Off-white |
| Optical Rotation | [α]/D -28.0±1.0 |
| Water Solubility | 43.2g/L(25 ºC) |
| Merck | 14,3101 |
| BRN | 619924 |
| InChI | 1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m0/s1 |
| InChIKey | WVXRAFOPTSTNLL-NKWVEPMBSA-N |
| SMILES | Nc1ncnc2n(cnc12)[C@H]3CC[C@@H](CO)O3 |
| CAS DataBase Reference | 4097-22-7(CAS DataBase Reference) |
| EPA Substance Registry System | Adenosine, 2',3'-dideoxy- (4097-22-7) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 34-36/37-22 |
| Safety Statements | 26-27-36/37/39-45-24/25 |
| WGK Germany | 2 |
| RTECS | AU7358900 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 oral in mouse: 5gm/kg |
Dideoxyadenosine Usage And Synthesis
| Chemical Properties | Beige power |
| Uses | A potent labelled anti-HIV agent. |
| Uses | A potent anti-HIV agent. |
| Uses | Dideoxy Adenosine (Didanosine EP Impurity G) is a potent anti-HIV agent. |
| Uses | 2′,3′-Dideoxyadenosine (ddA), a specific adenylyl cyclase inhibitor, is useful in biological process and pathway studies involving adenylyl cyclase activity and cAMP pool modulation. |
| Definition | ChEBI: A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine. |
| General Description | Off-white powder. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | Dideoxyadenosine may be sensitive to prolonged exposure to light. |
| Health Hazard | SYMPTOMS: Symptoms of exposure to a related compound include cutaneous eruptions, fever, mouth sores, thrombocytopenia, neutropenia, reversible peripheral neuropathy, gastrointestinal distress, headache, nausea and vomiting. |
| Fire Hazard | Flash point data for Dideoxyadenosine are not available; however, Dideoxyadenosine is probably combustible. |
Dideoxyadenosine Preparation Products And Raw materials
