DIETHYLCARBAMAZINE CITRATE CAS 1642-54-2
Introduction：Basic information about DIETHYLCARBAMAZINE CITRATE CAS 1642-54-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
DIETHYLCARBAMAZINE CITRATE Basic information
| Product Name: | DIETHYLCARBAMAZINE CITRATE |
| Synonyms: | EthylaMinoazine-d3 Citrate;Filaribits-d3;Filazine-d3;Franocide-d3;Franozan-d3;Hetrazan-d3;N,N-Diethyl-4-(Methyl-d3)-1-piperazinecarboxaMide 2-Hydroxy-1,2,3-propanetricarboxylate;N,N-Diethyl-4-(Methyl-d3)-1-piperazinecarboxaMide Citrate Salt |
| CAS: | 1642-54-2 |
| MF: | C16H29N3O8 |
| MW: | 391.42 |
| EINECS: | 216-696-6 |
| Product Categories: | HETRAZAN;Miscellaneous Reagents;Heterocyclic Building Blocks;Piperazines;Antibiotics A to Z;Antibiotics A-F;Antiparasitic / Antiprotozoal / Anthelminthic;C16 to C29;Spectrum of Activity;Antibiotics;Building Blocks;Chemical Synthesis |
| Mol File: | 1642-54-2.mol |
DIETHYLCARBAMAZINE CITRATE Chemical Properties
| Melting point | 140 °C |
| Boiling point | 516.39°C (rough estimate) |
| density | 1.1718 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very soluble in water, soluble in ethanol (96 per cent), practically insoluble in acetone. |
| form | powder |
| color | White to Almost white |
| Water Solubility | almost transparency |
| BRN | 3836352 |
| BCS Class | 1 |
| InChI | 1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| InChIKey | PGNKBEARDDELNB-UHFFFAOYSA-N |
| SMILES | OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1 |
| CAS DataBase Reference | 1642-54-2(CAS DataBase Reference) |
| EPA Substance Registry System | Diethylcarbamazine citrate (1642-54-2) |
Safety Information
| Hazard Codes | T+,T |
| Risk Statements | 22-26-23 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TL1225000 |
| TSCA | TSCA listed |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933595960 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 4 Oral |
| Hazardous Substances Data | 1642-54-2(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 1.38 g/kg (Harned) |
| Description | Diethylcarbamazine citrate is an odorless,white crystalline powder; Molecular weight=391.48;Freezing/Melting point=135-143℃. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 1, Reactivity 0. Soluble in water. |
| Chemical Properties | White or almost white, crystalline powder, slightly hygroscopic. |
| Originator | Hetrazan,Lederle,US,1949 |
| Uses | Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg. |
| Definition | ChEBI: Diethylcarbamazine citrate is a piperazinecarboxamide. |
| Manufacturing Process | To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochlorideand 8.34 grams of sodium hydroxide. When solution had been effected thebeaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxidedissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride wereadded simultaneously. When all had been added, the solution was extracted 3times with ether which was then dried and filtered. The ether solution wassaturated with dry hydrogen chloride. A yellow gum appeared which ontrituration gave a white, hygroscopic solid which was filtered and dried in adrying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamidehydrochloride had a melting point of 150°-155°C. If the compound itself is desired, the salt is dissolved in water and thesolution saturated with a mild alkali such as potassium carbonate. The productis then extracted with chloroform, dried, and after removal of the chloroform,distilled. |
| Therapeutic Function | Anthelmintic |
| General Description | Crystalline solid, scored white tablets. Used against filariasis in man and animals. |
| Health Hazard | (Non-Specific -- Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects. |
| Fire Hazard | When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat. |
| Safety Profile | Poison by inhalation and intravenous routes. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx. |
| Potential Exposure | Used against filariasis in humans andanimals. Especially popular in veterinary medicine(anthelmintic). |
| Veterinary Drugs and Treatments | Once the hallmark agent for heartworm disease prophylaxis in dogs,DEC is no longer commercially available in the USA (in oral veterinarydosage forms). DEC is approved for use for the prophylaxis ofheartwormdisease (D. immitis), and/or the treatment of ascariasisin dogs. The drug is also used in ferrets and zoo animals susceptibleto heartworm. DEC is used in dogs at higher dosages as alternativetherapyfor several other parasites (see Dosage section below). Someproducts were labeled for use in cats to treat ascarid infections. In cats, DEC may help alleviate the course (preventing lymphomadevelopment) of FeLV infection. In the U.K., DEC is used as an injectable product to control parasiticbronchitis (Dictyocaulus viviparous) in sheep and cattle. In humans, DEC is indicated as a filaricidal for the treatmentof Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocercavolvulus. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. |
| storage | Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. |
| Shipping | Medicine, solid, toxic, n.o.s. requires a label of“POISONOUS/TOXIC MATERIALS.” They fall in HazardClass 6.1. |
DIETHYLCARBAMAZINE CITRATE Preparation Products And Raw materials
| Raw materials | Sodium carbonate-->Diethylcarbamyl chloride-->Sodium hydroxide-->1-Methylpiperazine |
