Diethyleneglycol diacetate CAS 628-68-2

Introduction：Basic information about Diethyleneglycol diacetate CAS 628-68-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Diethyleneglycol diacetate Basic information

• Product Name: Diethyleneglycol diacetate
• Synonyms: 2,2’-oxybis-ethanodiacetate;2-[2-(Acetyloxy)ethoxy]ethyl acetate;aceticacid,oxydiethyleneester;aceticacid2-(2-acetoxy-ethoxy)-ethylester;Diglycol, diacetate;Ethanol,2,2’-oxybis-,diacetate;CAS_628-68-2;oxydiethylenedi(acetate)
• CAS: 628-68-2
• MF: C8H14O5
• MW: 190.19
• EINECS: 211-049-4
• Product Categories: Functional Materials;Plasticizer;Polyalcohol Ethers, Esters (Plasticizer)
• Mol File: 628-68-2.mol

Diethyleneglycol diacetate Chemical Properties

• Melting point: 19°C
• Boiling point: 200°C (estimate)
• density: 1.101 g/mL at 25 °C
• refractive index: n20/D 1.431
• Fp: >230 °F
• form: powder to lump to clear liquid
• color: White or Colorless to Almost white or Almost colorless
• InChI: 1S/C8H14O5/c1-7(9)12-5-3-11-4-6-13-8(2)10/h3-6H2,1-2H3
• InChIKey: UBPGILLNMDGSDS-UHFFFAOYSA-N
• SMILES: CC(=O)OCCOCCOC(C)=O
• LogP: 0.13 at 25℃
• CAS DataBase Reference: 628-68-2(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2,2'-oxybis-, diacetate(628-68-2)
• EPA Substance Registry System: Ethanol, 2,2'-oxybis-, diacetate (628-68-2)

Safety Information

• Hazard Codes: Xi
• Risk Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• RTECS: AJ1800000
• TSCA: TSCA listed
• HS Code: 29153900
• Storage Class: 10 - Combustible liquids
• Hazard Classifications: Eye Irrit. 2

Diethyleneglycol diacetate Usage And Synthesis

Uses

Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Definition

ChEBI: An acetate ester that is the diacetate obtained by the formal condensation of the two hydroxy groups of diethylene glycol with two molecules of acetic acid respectively.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005