Dihydrotanshinone I CAS 87205-99-0

Introduction：Basic information about Dihydrotanshinone I CAS 87205-99-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Dihydrotanshinone I Basic information

• Product Name: Dihydrotanshinone I
• Synonyms: (-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;Dihydrotanshinone I 87205-99-0;1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione;4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione;Dihydrotanshinone Ⅰ, froM Salvia Miltiorrhiza;(1R)-1,6-diMethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;Dihydrotanshinone I;15,16-Dihydrotanshine I
• CAS: 87205-99-0
• MF: C18H14O3
• MW: 278.3
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 87205-99-0.mol

Dihydrotanshinone I Chemical Properties

• Melting point: 214.0 to 218.0 °C
• Boiling point: 479.2±45.0 °C(Predicted)
• density: 1.32±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: ethanol: soluble1mg/mL, clear, orange to red
• form: powder
• color: red
• biological source: Salvia miltiorrhiza
• λmax: 239nm(lit.)
• Major Application: metabolomics vitamins, nutraceuticals, and natural products
• InChI: 1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
• InChIKey: HARGZZNYNSYSGJ-JTQLQIEISA-N
• SMILES: C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O

Safety Information

• Hazard Codes: Xn,N
• Risk Statements: 22-50
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: SF8282630
• HS Code: 29329990
• Storage Class: 11 - Combustible Solids
• Hazardous Substances Data: 87205-99-0(Hazardous Substances Data)

Dihydrotanshinone I Usage And Synthesis

Chemical Properties

Red powder

Uses

Dihydrotanshinone I, an extract from Salvia miltiorrhiza Bunge, is an anti-cancer agent which has been shown to induce apoptosis in human colorectal cancer cells.

Definition

ChEBI: Dihydrotanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent.

Biological Activity

Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.

in vivo

Dihydrotanshinone I (10 and 25 mg/kg) significantly attenuates atherosclerotic plaque formation, alteres serum lipid profile, decreases oxidative stress and shrinks necrotic core areas in ApoE^-/- mice. Dihydrotanshinone I dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta^[1].
Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats^[2].