Introduction：Basic information about Dimetotiazine CAS 7456-24-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dimetotiazine Basic information
| Product Name: | Dimetotiazine |
| Synonyms: | Dimetotiazine;10-(2-dimethylaminopropyl)-N,N-dimethyl-phenothiazine-2-sulfonamide: m ethanesulfonic acid;10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide;10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-;Dimethiotazine;Dimethothiazine;Fonazine;Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl- (6CI, 7CI, 8CI) |
| CAS: | 7456-24-8 |
| MF: | C19H25N3O2S2 |
| MW: | 391.557 |
| EINECS: | 2312296 |
| Product Categories: | |
| Mol File: | 7456-24-8.mol |
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Dimetotiazine Chemical Properties
| Boiling point | 533.7±60.0 °C(Predicted) |
| density | 1.1822 (rough estimate) |
| refractive index | 1.6560 (estimate) |
| pka | 8.91±0.50(Predicted) |
Safety Information
Dimetotiazine Usage And Synthesis
| Originator | Migristene,Rhone Poulenc,France,1965 |
| Uses | Serotonin inhibitor. |
| Definition | ChEBI: Dimetotiazine is a member of phenothiazines. |
| Manufacturing Process | A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc)is heated under reflux for 3 hours with sodium amide (1.5 grams). A solutionof 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc)is then added and heating under reflux continued for 4 hours. After coolingthe suspension obtained is agitated with water (50 cc) and ether (30 cc). Theaqueous layer is separated and the basic products are extracted from theorganic phase with 10% hydrochloric acid. The xylene layer is discarded and,after the combined acid solutions have been made alkaline with sodiumcarbonate, the base is extracted with chloroform. The chloroform solutions arethen washed with water and dried over anhydrous potassium carbonate. Afterevaporation of the solvent under reduced pressure there is obtained a cruderesinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base inisopropanol and recrystallization from anhydrous ethanol of the salt formed,there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl)phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. Afterdissolving the product in anhydrous ethanol and adding methanesulfonic acidthere is obtained fonazine mesylate. |
| in vivo | Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats[2]. | Animal Model: | Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)[2] | | Dosage: | 0.5, 1, 2, 4, 8 and 16 mg/kg | | Administration: | i.v.; single dosage | | Result: | Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.
Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.
Reduced the activity of the dynamic fusimotor fibres. |
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Dimetotiazine Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->1-DIMETHYLAMINO-2-CHLOROPROPANE-->Sodium amide-->Methanesulfonic acid |
