DIPHENYL PHOSPHITE CAS 4712-55-4
DIPHENYL PHOSPHITE Basic information
| Product Name: | DIPHENYL PHOSPHITE |
| Synonyms: | Diphenyl phosphite, contains varying amounts of phenol and (C6H5O)3P;Phosphonic acid diphenyl;Phosphorous acid diphenyl;Diphenyl Phosphite (contains 5% Phenol at maximum);Diphenyl PhosphonatePhosphonic Acid Diphenyl EsterPhosphorous Acid Diphenyl Ester;(contains 5% Phenol at MaxiMuM);Diphenyl Phosphite Diphenyl phosphite, contains varying aMounts of phenol and (C6H5O)3P 5GR |
| CAS: | 4712-55-4 |
| MF: | C12H11O3P |
| MW: | 234.19 |
| EINECS: | 225-202-8 |
| Product Categories: | Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds |
| Mol File: | 4712-55-4.mol |
DIPHENYL PHOSPHITE Chemical Properties
| Melting point | 12 °C (lit.) |
| Boiling point | 218-219 °C/26 mmHg (lit.) |
| density | 1.223 g/mL at 25 °C (lit.) |
| vapor density | 8.1 (vs air) |
| vapor pressure | 5 mm Hg ( 140 °C) |
| refractive index | n |
| Fp | 350 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Liquid |
| color | Clear |
| Specific Gravity | 1.223 |
| BRN | 2051909 |
| InChI | 1S/C12H11O3P/c13-16(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h1-10,16H |
| InChIKey | OGBPILLJZSJJRC-UHFFFAOYSA-N |
| SMILES | O=[PH](Oc1ccccc1)Oc2ccccc2 |
| LogP | 2.4 at 25℃ and pH7 |
| CAS DataBase Reference | 4712-55-4(CAS DataBase Reference) |
| EPA Substance Registry System | Diphenyl phosphite (4712-55-4) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| RIDADR | 1760 |
| WGK Germany | 3 |
| F | 21 |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29209090 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
| Chemical Properties | clear liquid |
| Uses | Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity. |
| Synthesis | 2310-89-6 108-95-2 4712-55-4 In a three-necked round-bottomed flask equipped with a mechanical stirrer, a reflux condenser and a dropping funnel, the first P-O component (PIII-OH) is added under nitrogen protection. This P-O component (see column 5 of Table 1) may be selected from H3PO3, monoalkyl phosphite or mixtures thereof and may additionally comprise dialkyl phosphite. Subsequently, the first P-O component is heated to the temperature specified in column 11 of Table 1 (T° step a) for step a). Next, the second P-O component (see column 6 of Table 1) is added while maintaining the appropriate temperature. The mixture was allowed to react for the time indicated in column 13 of Table 1 (reaction time step a), followed by step b). The alcohol R1-OH (see column 3 of Table 1) is then added dropwise while maintaining the temperature specified in column 12 of Table 1 (T° step b). After the mixture was reacted for the time indicated in column 14 of Table 1 (reaction time b), it was cooled to room temperature and analyzed by 31P NMR. |
| Purification Methods | Diphenyl Phosphite can be purified by distillation. Best done in small batches since decomposition frequently occurs. Phenol can be substantially removed by heating at 150 °C at water pump vacuum. |
| References | [1] Patent: EP2581378, 2013, A1. Location in patent: Paragraph 0038; 0039; 0043 |
DIPHENYL PHOSPHITE Preparation Products And Raw materials
| Raw materials | phenyl hydrogen phosphonate-->Phenol-->Phosphorus pentoxide-->1,4-Dioxane |
| Preparation Products | DIPHENYL METHYLPHOSPHONATE-->DIPHENYL PHOSPHORAMIDATE-->PHENYL PHOSPHORODICHLORIDITE-->phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate-->GB-1-->DIPHENYL CYANOPHOSPHONATE |
