DMT-2'O-Methyl-rU Phosphoramidite CAS 110764-79-9
Introduction：Basic information about DMT-2'O-Methyl-rU Phosphoramidite CAS 110764-79-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
DMT-2'O-Methyl-rU Phosphoramidite Basic information
| Product Name: | DMT-2'O-Methyl-rU Phosphoramidite |
| Synonyms: | 3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-METHOXYOXOLA;DMT-2'O-ME-RU AMIDITE 0.5G 89 SINGLE;2'-O-methyluridine-ce phosphoramidite*for abi;DMT-2'O-Me-rU Amidite 10g, Single;DMT-2'O-ME-RU AMIDITE 0.5G AB SINGLE;2’-O-Methy-rUPhosphoramidite;N-blocked-5'-O-DMT-2'-O-Me CED uridine phosphoramidite;5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite |
| CAS: | 110764-79-9 |
| MF: | C40H49N4O9P |
| MW: | 760.82 |
| EINECS: | 200-100-5 |
| Product Categories: | |
| Mol File: | 110764-79-9.mol |
DMT-2'O-Methyl-rU Phosphoramidite Chemical Properties
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO : 100 mg/mL (131.44 mM; Need ultrasonic) |
| pka | 9.39±0.10(Predicted) |
| form | powder |
| color | white to off-white |
| biological source | non-animal source (no BSE/TSE risk) |
| InChIKey | UVUOJOLPNDCIHL-XKZJCBTISA-N |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,36,39,r| |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Characteristics | DMT-2′O-Methyl-rU Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. Its key features include: High yield of crude oligonucleotides Compatible with DNA synthesis; Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides; Recommended deprotection conditions are 8 hours at 55°C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65°C; Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation; Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers); 2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry. |
| Uses | DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research. |
| Application | 2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rU Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of: Diagnostic probes Aptamer and ribozyme development Mixed 2′O-Methyl-RNA/DNA antisense molecules |
DMT-2'O-Methyl-rU Phosphoramidite Preparation Products And Raw materials
| Raw materials | 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE-->2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite |
