EG-011 CAS 2377113-41-0

Introduction：Basic information about EG-011 CAS 2377113-41-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

EG-011 Basic information

• Product Name: EG-011
• Synonyms: EG-011;Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione, 3-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1-[(4-phenoxyphenyl)methyl]-
• CAS: 2377113-41-0
• MF: C28H26N4O4
• MW: 482.53
• Mol File: 2377113-41-0.mol

EG-011 Chemical Properties

• Boiling point: 710.1±70.0 °C(Predicted)
• density: 1.312±0.06 g/cm3(Predicted)
• pka: 2.25±0.20(Predicted)
• form: Solid
• color: White to off-white

EG-011 Usage And Synthesis

Uses

EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas[1][2][3].

in vivo

EG-011 (200 mg/kg; i.p.; 5 days per week) delays tumor growth (Day 6, Day 7, Day 9) and tumor weight in female NOD-SCID mice with the MCL REC-1 cell line. EG-011-treated tumors are 2.2-fold smaller than controls (P<0.001)^[1].

References

[1] E. Gaudio, et al. EG-011 IS A NOVEL SMALL MOLECULE WITH IN VITRO AND IN VIVOANTI-TUMOR ACTIVITY AGAINST LYMPHOMA. Hematological OncologyVolume 37: 15th International Conference on Malignant Lymphoma Palazzo dei Congressi, Lugano, Switzerland, 18-22 June, 2019.
[2] Filippo Spriano, et al. Abstract 1817: EG-011 is a first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity. Cancer Res (2022) 82 (12_Supplement): 1817.
[3] F. Spriano, et al. The first-in-class WASP activator EG-011 is active in lymphoma and multiple myeloma cell lines resistant to FDA approved compounds. European Journal of Cancer 174S1 (2022) S3-S128.