Escin CAS 6805-41-0
Introduction：Basic information about Escin CAS 6805-41-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Escin Basic information
| Product Name: | Escin |
| Synonyms: | BETA-AESCIN;ESCIN;Chestnuts extract;AESCIN;(2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid;a-4700;aescusan;amorphousaescin |
| CAS: | 6805-41-0 |
| MF: | C55H86O24 |
| MW: | 1131.26 |
| EINECS: | 229-880-6 |
| Product Categories: | Inhibitors;Herb extract |
| Mol File: | 6805-41-0.mol |
Escin Chemical Properties
| Melting point | 224.5°C |
| Boiling point | 764.81°C (rough estimate) |
| density | 1.1200 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in methanol. |
| form | powder |
| color | white |
| biological source | plant (Aesculus chinensis) |
| Merck | 13,3730 |
| Stability: | Hygroscopic |
| Cosmetics Ingredients Functions | TONIC |
| InChIKey | AXNVHPCVMSNXNP-YSYFQUGBSA-N |
| CAS DataBase Reference | 6805-41-0 |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-20/22 |
| Safety Statements | 22-24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | KF6296000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
| Chemical Properties | saponin mixture |
| Originator | Aescin,Sinochem |
| Uses | membrane permeabilizer |
| Uses | escin is a saponin occurring in the seed of the horse chestnut tree. |
| Uses | Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling. |
| Manufacturing Process | The 1st method of preparation of escin (US Patent No. 3,238,190): 500 g of pulverized horse chestnut seeds were extracted two times for 1 hourwith 2.5 L each of aqueous 50% methanol with stirring. The solution wasfiltered, additional methanol was added thereto to increase the methanolconcentration to 65%, and then it was filtered again. The obtained solutioncontaining the extracted saponin had a pH of 5 and was passed through acolumn of 500 ml (wet volume) of cation exchange resin (Lewatit S-100 ofFarben-fabriken Bayer A.G.) which had been treated with 65% methanolic 1%sulfuric acid and then had been washed neutral with 65% methanol. Thesolution leaving the resin had a pH in the range of about 3 to 4 and wasconcentrated by distillation to about 4/5 of its original volume. On cooling,crystallization of the escin started and the solution was allowed to stand untilthe crystallization had been completed. Escin having a melting point of 224-226°C was obtained in a yield of 2%, calculated on the starting material. The 2st method of preparations of escin (US Patent No. 3,163,636): An ethereal solution of 1 kg of cholesterol is added to 100 kg of a 10%aqueous-alcoholic horse extract. The resulting emulsion is stirred at 90°C for1 hour, while the ether is distilled off. The water insoluble saponin-cholesterolprecipitate is centrifuged and washed with cold water until the wash water iscolorless. The precipitate is air-dried at room temperature. The resulting dustfine powder is extracted with ether in a Soxhlet apparatus for 10 days. Theresidue is treated with 20 kg of methanol and the undissolved material isfiltered off. The yellowish methanol solution is treated with activated charcoaluntil it is colorless. The methanol is distilled off in a vacuum, and the residueis dried over phosphorus pentoxide in a vacuum not exceeding 1 mm Hg. Theyield of pure sodium escinate obtained thereby is about 0.8 kg (8%). |
| Therapeutic Function | Antiedemic, Capillary protective |
| General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG |
| Flammability and Explosibility | Non flammable |
Escin Preparation Products And Raw materials
| Raw materials | Methanol-->Cholesterol |
