Introduction：Basic information about Etelcalcetide CAS 1262780-97-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Etelcalcetide Basic information
| Product Name: | Etelcalcetide |
| Synonyms: | Etelcalcetide;D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine;AMG-416 (Velcalcetide);Parsavib;S-(((S)-2-Acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-oxopropyl)thio)-L-cysteine |
| CAS: | 1262780-97-1 |
| MF: | C38H73N21O10S2 |
| MW: | 1048.25 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 1262780-97-1.mol |
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Etelcalcetide Chemical Properties
| density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 2.01±0.10(Predicted) |
| Sequence | H-Cys(1)-OH,Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2(Disulfide bridge Cys1-(D-Cys1))/C(1),Ac-（D-C（1）-（D-A）-（D-R）-（D-R）-（D-R）-（D-A）-（D-R）-NH2(Disulfide bridge Cys1-(D-Cys1)) |
| InChIKey | HQGWMVNIZKNABK-TZUZSESWNA-N |
Safety Information
Etelcalcetide Usage And Synthesis
| Uses | N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl- D-Argininamide-L-cysteine Disulfide is a useful research chemical used in the treatment of chronic kidney disease-??mineral and bone disorder. |
| Definition | ChEBI: Etelcalcetide is an oligopeptide. |
| Mechanism of action | Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion. |
| Clinical Use | Synthetic peptide calcimimetic agent:Treatment of secondary hyperparathyroidism in patients on haemodialysis |
| Drug interactions | Potentially hazardous interactions with other drugs Avoid with cinacalcet. |
| Metabolism | Etelcalcetide is biotransformed in blood by reversible disulphide exchange with endogenous thiols to predominantly form conjugate with serum albumin |
Etelcalcetide Preparation Products And Raw materials
