Introduction：Basic information about Etidocaine CAS 36637-18-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Etidocaine Basic information
| Product Name: | Etidocaine |
| Synonyms: | Duranest;W-19053;Etidocaine HCL;ButanaMide, N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)-;N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide;Etidocaine USP/EP/BP;EDC,Inhibitor,inhibit,Etidocaine,anesthetics;Etidocaine, 10 mM in DMSO |
| CAS: | 36637-18-0 |
| MF: | C17H28N2O |
| MW: | 276.42 |
| EINECS: | 253-143-8 |
| Product Categories: | |
| Mol File: | 36637-18-0.mol |
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Etidocaine Chemical Properties
| Boiling point | 389.7±30.0 °C(Predicted) |
| density | 0.993±0.06 g/cm3(Predicted) |
| pka | 14.18±0.70(Predicted) |
Safety Information
Etidocaine Usage And Synthesis
| Originator | Duranest,Astra,US,1976 |
| Uses | Anesthetic (local). |
| Definition | ChEBI: An amino acid amide in which 2-[ethyl(propyl)amino]butanoic acid and 2,6-dimethylaniline have combined to form the amide bond. Used as a local anaesthetic (amide caine), it has rapid onset and long action properties, similar to bupivacaine, and is given b injection during surgical procedures and during labour and delivery. |
| Manufacturing Process | α-(n-Propylamino)-n-butyro-2,6-xylidide(0.243 mol) and freshly distilleddiethyl sulfate (1.6 mols were mixed in a flask equipped with reflux condenser,drying tube and stirrer. The mixture was stirred for 5 hours at 90°C. Aftercooling, water (110 ml) was added with stirring for 15 minutes followed by 4MHCl (110 ml). The solution was washed with ether (3 X 100 ml) and madealkaline with 7M NaOH to pH 10-11. The freed base was taken up in ether (3X 100 ml); the extracts were dried over sodium sulfate, filtered andevaporated. The residue was dissolved in absolute ether (200 ml) and thehydrochloride prepared by addition of ethereal hydrogen chloride. Theprecipitate was filtered, washed with ether, and recrystallized twice fromabsolute ethanol/ether and from isopropanol/isopropylether; MP 203°C to203.5°C; yield: 0.126 mol (52%).The starting material is prepared by reacting 2-bromobutyric acid with sulfonylchloride to give the acid chloride. It is then reacted with 2,6-xylidine, thenwith potassium iodide followed by n-propylamine. |
| Brand name | Duranest [as hydrochloride] (Astra). |
| Therapeutic Function | Local anesthetic |
Etidocaine Preparation Products And Raw materials
