Introduction：Basic information about CAS 36637-18-0|etidocaine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | etidocaine |
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| CAS Number | 36637-18-0 | Molecular Weight | 276.417 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 389.7±30.0 °C at 760 mmHg |
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| Molecular Formula | C17H28N2O | Melting Point | / |
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| MSDS | / | Flash Point | 189.5±24.6 °C |
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Names
| Name | etidocaine |
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| Synonym | More Synonyms |
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etidocaine BiologicalActivity
| Description | Etidocaine (EDC) is a long aminoamide local anesthetic[1]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | IGL-EDC formulations can induce a significant increase in human fibroblasts survival[1]. Cell Viability Assay[1] Cell Line: Human fibroblasts cells Concentration: 0, 4, 8, 16, 24 mM Incubation Time: 4, 6 and 24 h Result: Showed that cell survival decreased in a (EDC) concentration with time-dependent manner. |
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| In Vivo | Etidocaine (spinal injection, 0.0075%, once) does not show postinjection neurologic deficit[2]. Animal Model: Adult Swiss Webster male mice[2] Dosage: 0.0075% Administration: Etidocaine (spinal injection, 0.0075%, once) Result: Did not show postinjection neurologic deficit. |
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| References | [1]. Oliveira, et al. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharmaceutical research vol. 35, 12 229. 10 Oct. 2018. [2]. Langerman, L, et al. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model. Anesthesia and analgesia vol. 79,3 (1994): 490-4. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 389.7±30.0 °C at 760 mmHg |
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| Molecular Formula | C17H28N2O |
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| Molecular Weight | 276.417 |
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| Flash Point | 189.5±24.6 °C |
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| Exact Mass | 276.220154 |
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| PSA | 32.34000 |
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| LogP | 3.77 |
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| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
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| Index of Refraction | 1.532 |
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| InChIKey | VTUSIVBDOCDNHS-UHFFFAOYSA-N |
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| SMILES | CCCN(CC)C(CC)C(=O)Nc1c(C)cccc1C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EJ3595000
- CHEMICAL NAME :
- Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (+-)-
- CAS REGISTRY NUMBER :
- 36637-18-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C17-H28-N2-O
- MOLECULAR WEIGHT :
- 276.47
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 42,201,1990
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Synonyms
| (2S)-N-(2,6-Dimethylphenyl)-2-[ethyl(propyl)amino]butanamide |
| Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (2S)- |
| 2-ethylpropylamino-2,6-n-butyroxylidide |
| Etidocaine |
