Introduction：Basic information about Etymemazine CAS 523-54-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Etymemazine Basic information
| Product Name: | Etymemazine |
| Synonyms: | Etymemazine;2-Ethyl-N,N,β-trimethyl-10H-phenothiazine-10-propan-1-amine;Diquel;Ethotrimeprazine;Ethylisobutrazine;RP-6484;Etymemazine [inn];Unii-861J4K81C7 |
| CAS: | 523-54-6 |
| MF: | C20H26N2S |
| MW: | 326.5 |
| EINECS: | |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol File: | 523-54-6.mol |
|
Etymemazine Chemical Properties
| Boiling point | 457.6±45.0 °C(Predicted) |
| density | 1.085±0.06 g/cm3(Predicted) |
| pka | 9.34±0.28(Predicted) |
Safety Information
Etymemazine Usage And Synthesis
| Originator | Nuital,Vaillant-Defresne |
| Uses | A derivative of Phenothiazine, an antibacterial compound. |
| Definition | ChEBI: Etymemazine is a member of phenothiazines. |
| Manufacturing Process | 2.33 g 95% sodium amide were added to a boiling solution of 11.35 g 2-ethyl-10H-phenothiazine (BP: 135°-136°C) in 150 ml dry xylene by stirring atreflux for 1.5 hours. The solution of 7.72 g of 1-dimethylamino-2-methyl-3-chloropropane in 90 ml of dry xylene was poured in the above solution at thesame temperature for 45 minutes. The mixture was heated at reflux else 18hours. On cooling it was stirred with the mixture of 70 ml 1 Nmethanesulfonic acid and 40 ml water whereupon a xylene layer wasremoved. The water layer was extracted with 200 ml ether and basified with10 ml NaOH (d=1.33), again extracted with ether and dried over potassiumcarbonate. The ether was distilled off, a residue was distilled to give 10-(3-dimethylamino-2-methylpropyl)-2-ethylphenothiazine; BP: 162°-182°C/0.45mm.
The prepared base was in 60 ml acetone dissolved and 24.5 ml 1.7 N HCl wasadded and a precipitate of ethyl-2-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine chlorohydrate dropped out. It was filtered off, washed withacetone and ether and dried. MP: 160°-163°C. |
| Therapeutic Function | Neuroleptic, Antihistaminic, Hypnotic |
Etymemazine Preparation Products And Raw materials
| Raw materials | Sodium amide-->2-ethyl-10H-phenothiazine-->Methanesulfonic acid-->3-Dimethylamino-2-methylpropyl chloride hydrochloride |
