Introduction：Basic information about Faropenem CAS 106560-14-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Faropenem Basic information
| Product Name: | Faropenem |
| Synonyms: | (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]-;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)-;6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate;Faropenem sodium hemipentahydrate;FAROPENEM;FROPENEM |
| CAS: | 106560-14-9 |
| MF: | C12H15NO5S |
| MW: | 285.32 |
| EINECS: | 1312995-182-4 |
| Product Categories: | API |
| Mol File: | 106560-14-9.mol |
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Faropenem Chemical Properties
| Boiling point | 570.2±50.0 °C(Predicted) |
| density | 1.56±0.1 g/cm3(Predicted) |
| pka | 4.00±0.40(Predicted) |
| CAS DataBase Reference | 106560-14-9 |
Safety Information
Faropenem Usage And Synthesis
| Description | Farom was launched in Japan for use as an antibiotic against commonrespiratory tract pathogens. It can be prepared by several related routes of aboutseven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylatedazetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable.Farom is the most active β-lactam against anaerobes (more than cefaclor, cefiximeand amoxicillin) but also has activity against Gram-positive, Gram-negative andenterobacteriaceae. It is equally active against strains carrying plasmid andchromosome mediated β-lactamases. The short plasma elimination half-life is theresult of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis byextended spectrum β-lactamases than some second and third generationcephalosporins. |
| Originator | Suntory (Japan) |
| Uses | Faropenem (cas# 106560-14-9) is a compound useful in organic synthesis. |
| Uses | Treatmentof bacterial infections. |
| Definition | ChEBI: 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid is a faropenem. It is a conjugate acid of a 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylate. |
| Brand name | Farom |
| Antimicrobial activity | An orally active penem with a broad spectrum of antibacterialactivity, including activity against selected anaerobicpathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens,Enterobacter spp. and some Providencia spp. It generallyretains activity against many Gram-positive organisms,but has no useful activity against Ps. aeruginosa. It hasreduced activity against E. faecium, methicillin-resistantStaph. aureus (MRSA) and some strains of coagulase-negativestaphylococci. It is stable to hydrolysis by extendedspectrum β-lactamases, but is hydrolyzed by carbapenemases.Esterified prodrugs with increased bioavailabilityhave been studied in clinical trials but have not receivedregulatory approval. |
Faropenem Preparation Products And Raw materials
| Raw materials | Oxalyl chloride-->N,N-Diisopropylethylamine-->Chloromethane-->Silver nitrate-->Triethyl phosphate-->Tetrabutylammonium periodate-->Triphenylmethanethiol |
