Flusilazole CAS 85509-19-9
Introduction：Basic information about Flusilazole CAS 85509-19-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Flusilazole Basic information
| Product Name: | Flusilazole |
| Synonyms: | (bis(4-fluorophenyl))(methyl)(1h-1,2,4-triazol-1-ylmethyl)-silan;4-triazole,1-((bis(4-fluorophenyl)methylsilyl)methyl)-1h-2;dpx-h6573;1H-1,2,4-Triazole, 1-bis(4-fluorophenyl)methylsilylmethyl-;flusilazole (ansi,bsi,iso);flusilazole (ISO) bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane;Benocarp;Flusilazole 100mg [85509-19-9] |
| CAS: | 85509-19-9 |
| MF: | C16H15F2N3Si |
| MW: | 315.4 |
| EINECS: | |
| Product Categories: | ConazolesAlphabetic;Alpha sort;ConazolesPesticides&Metabolites;E-GAlphabetic;F;FA - FL;Fungicide;Special Silanes;Fungicides;Pesticides |
| Mol File: | 85509-19-9.mol |
Flusilazole Chemical Properties
| Melting point | 55° |
| Boiling point | 393 °C [760mmHg] |
| density | 1.17 |
| vapor pressure | 3.9 x l0-8 Pa (25 °C) |
| refractive index | 1.563 |
| Fp | 192°C |
| storage temp. | 0-6°C |
| solubility | DMSO : 100 mg/mL (317.07 mM; Need ultrasonic) |
| pka | 2.5 at 25℃ |
| form | Solid |
| Water Solubility | 900 mg l-1 (pH 1.1), 50 mg l-1 (pH 5.7),45 mg l-1 (pH 7.8) at 25 °C |
| color | White to off-white |
| biological source | mouse |
| Merck | 13,4232 |
| BRN | 5824097 |
| Major Application | agriculture cleaning products cosmetics environmental food and beverages personal care |
| InChI | 1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 |
| InChIKey | FQKUGOMFVDPBIZ-UHFFFAOYSA-N |
| SMILES | C[Si](Cn1cncn1)(c2ccc(F)cc2)c3ccc(F)cc3 |
| CAS DataBase Reference | 85509-19-9(CAS DataBase Reference) |
| EPA Substance Registry System | Flusilazole (85509-19-9) |
Safety Information
| Hazard Codes | T;N,N,T |
| Risk Statements | 61-22-40-51/53 |
| Safety Statements | 53-45-61 |
| RIDADR | UN 2588 |
| WGK Germany | 3 |
| RTECS | XZ4105000 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Carc. 2 Repr. 1B |
| Toxicity | LD50 in male, female rats (mg/kg): 1110, 674 orally; in rabbits >2000 dermally (Fort, Moberg) |
| Chemical Properties | Brown-red viscous liquid |
| Uses | Flusilazole is a silicon-containing triazole fungicide. Flusilazole is used to control fungal infections on a variety of fruit and vegetable crops |
| Uses | Agricultural fungicide. |
| Uses | Flusilazole is a broad spectrum fungicide used to control fungaldisease caused by pathogens of the Ascomycetes, Basidiomycetes andDeuteromycetes families. Flusilazole exhibits curative and preventativeactivities and is recommended for use in agriculture, horticulture andviticulture. Diseases controlled include eyespot, mildew, and rusts ofcereals, cercospora and rust of sugar beets, leaf spots of oilseed rape,scab and mildew of pome and stone fruits, mildew and black rot ofgrapes and Sigatoka disease of bananas. |
| Definition | ChEBI: Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an environmental contaminant, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of monofluorobenzenes, a member of triazoles, an organosilicon compound, a conazole fungicide and a triazole fungicide. |
| Metabolic pathway | Flusilazole is stable to aqueous hydrolytic and photolytic degradation.Although flusilazole is relatively stable in soil and is detected in plant andanimal samples, numerous degradation products have been reported. Theprimary metabolic pathway involves the cleavage of the methylenesiliconor/and methylene-triazole linkage. Another primary pathwayinvolves aryl hydroxylation followed by conjugation. The primarymetabolic/degradation pathways of flusilazole in soil, plant and animalsare presented in Scheme 1. |
| Degradation | Aqueous hydrolysis and photolysis are not sigruficant degradation pathwaysfor flusilazole (1). Flusilazole was stable (<5% decomposition) insterile buffers at pH 5, 7 and 9 (25 °C) for 34 days (Cadwgan, 1983). Nosignificant degradation was observed when fusilazole was irradiated withsimulated sunlight for 30 days at 300-450 nm in sterile buffer solution atpH 7 (Carter, 1986). |
Flusilazole Preparation Products And Raw materials
| Raw materials | n-Butyllithium-->Fluorobenzene-->Silicon tetrahydride-->METHYLSILANE-->1,2,4-Triazolylsodium |
