Introduction：Basic information about Flutropium bromide CAS 63516-07-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Flutropium bromide Basic information
| Product Name: | Flutropium bromide |
| Synonyms: | [8-(2-Fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide;flutropium bromide;(endo，syn)-8-(2-Fluoroethyl)-3-[(hydroxyl-diphenylaeetyl)oxy]-8-methyl-8-azoniabicyclo[3．2．1]octane bromide;Flutropium;8-Azoniabicyclo[3.2.1]octane, 8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-, bromide, (3-endo,8-syn)-;8-Azoniabicyclo[3.2.1]octane, 8-(2-fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-, bromide, (endo,syn)-;Ba 598Br;Flubron |
| CAS: | 63516-07-4 |
| MF: | C24H29BrFNO3 |
| MW: | 478.39 |
| EINECS: | 1533716-785-6 |
| Product Categories: | |
| Mol File: | 63516-07-4.mol |
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Flutropium bromide Chemical Properties
| Melting point | 192-193° (dec); mp 198-199° (dec) |
Safety Information
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner) |
Flutropium bromide Usage And Synthesis
| Description | Flutropium bromide is an antitussive useful in the treatment of allergic rhinitis and in thesymptomatic relief of bronchial asthma and chronic bronchitis. Recent studies suggest thatflutropium bromide may have potential as a long-acting alternative toP-sympathomimetics or the xanthines in the prophylaxis of obstructive airways disease. |
| Chemical Properties | White crystals from acetonitrile, melting point 192-193°C: (decomposition); crystals from ethanol-acetone, melting point 198-199°C (decomposition). Acute toxicity LD50 male and female mice, male and female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 IV; 760, 810, 830, 740 oral. |
| Originator | Boehringer Ingelheim (W.Germany) |
| Definition | ChEBI: Flutropium bromide is the organic bromide salt of flutropium. It is used in Japan for the treatment asthma and chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist, an antispasmodic drug and an anti-asthmatic drug. It contains a flutropium. |
| Brand name | Flubron |
Flutropium bromide Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->Dichloromethane-->Potassium permanganate-->Tropine-->2,2-Diphenylacetic acid-->FLUOROETHANE |
