Introduction：Basic information about Flutriafol CAS 76674-21-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Flutriafol Basic information
| Product Name: | Flutriafol |
| Synonyms: | FLUTRIAFOL;CINCIT(R);ATOUT(R);alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1h-1,2,4-triazole-1-ethanol;(RS)-2,4-difluoro-α-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol;FLUTRIAFOL SOLUTION 100 NG/MYL IN ACETON ITRILE, PESTANAL;Flutriafol TC;1H-1,2,4-Triazole-1-ethanol, .alpha.-(2-fluorophenyl)-.alpha.-(4-fluorophenyl)- |
| CAS: | 76674-21-0 |
| MF: | C16H13F2N3O |
| MW: | 301.29 |
| EINECS: | |
| Product Categories: | Agriculture;Alpha sort;ConazolesPesticides&Metabolites;E-GAlphabetic;F;FA - FL;Fungicides;Pesticides |
| Mol File: | 76674-21-0.mol |
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Flutriafol Chemical Properties
| Melting point | 130° |
| Boiling point | 506.5±60.0 °C(Predicted) |
| density | 1.3015 (estimate) |
| vapor pressure | 7.1 x l0-9 Pa (20 °C) |
| Fp | 2 °C |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 11.60±0.29(Predicted) |
| form | Solid |
| Water Solubility | 130 mg l-1 (pH 7,20 °C) |
| color | White to Off-White |
| Merck | 13,4240 |
| BRN | 8155287 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Major Application | agriculture
environmental |
| InChI | 1S/C16H13F2N3O/c17-13-7-5-12(6-8-13)16(22,9-21-11-19-10-20-21)14-3-1-2-4-15(14)18/h1-8,10-11,22H,9H2 |
| InChIKey | JWUCHKBSVLQQCO-UHFFFAOYSA-N |
| SMILES | OC(Cn1cncn1)(c2ccc(F)cc2)c3ccccc3F |
| LogP | 2.290 |
| CAS DataBase Reference | 76674-21-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Flutriafol(76674-21-0) |
| EPA Substance Registry System | Flutriafol (76674-21-0) |
Safety Information
| Hazard Codes | Xn,F |
| Risk Statements | 22-36-20/21/22-11 |
| Safety Statements | 22-24/25-36-26 |
| RIDADR | UN 1648 3/PG 2 |
| WGK Germany | 3 |
| RTECS | XZ4825000 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 2 |
| Toxicity | LD50 male, female rats (mg/kg): 1140, 1480 orally; rats, rabbits: >1000, >2000 percutaneously (Skidmore) |
Flutriafol Usage And Synthesis
| Chemical Properties | solid |
| Uses | Flutriafol is a systemic fungicide of the triazole class. Flutriafol has broad spectrum fungicidal activity and is used to control effectively cereal powdery mildew, cloud disease, leaf spot disease and rust disease. |
| Uses | Agricultural fungicide. |
| Uses | Flutriafol is used to control a wide variety of leaf and ear diseasesin cereals. It is also used in seed treatment formulations to control themajor soil-borne and seed-borne diseases of cereals. |
| Definition | ChEBI: 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol is a tertiary alcohol that is ethanol in which one of the hydrogens at position 1 is replaced by an p-fluorophenyl group, the other hydrogen at position 1 is replaced by a p-fluorophenyl group, and one of the hydrogens at position 2 is replaced by a 1H-1,2,4-triazol-1-yl group. It is a member of triazoles, a tertiary alcohol and a member of monofluorobenzenes. |
| Synthesis | Anhydrous potassium fluoride was reacted with 2,3,4,5-tetrachloronitrobenzene in anhydrous dimethylformamide at 140??C for 15 hours to obtain 2,4-difluoro-3,5-dichloronitrobenzene, and then the reaction was carried out in acetic acid at 95-100??C for 8 hours with iron powder reduction to obtain 2,4-difluoro-3,5-dichlorobenzenamine. -2,6-difluorobenzamide reacted with oxalyl chloride in toluene at reflux for 5 hours to obtain 2,6-difluorobenzoyl isocyanate, and then reacted with the above mentioned 2,4-difluoro-3,5-dichloroaniline in toluene at room temperature for 15 hours, and the white solid powder obtained was powdery mildew. |
| Metabolic pathway | Flutriafol is stable to hydrolysis and to light and it is persistent in soils. Incrops, the metabolites identified were derivatives of triazole. |
| Degradation | Flutriafol, 1, is stable to hydrolysis at pH 5,7 and 9 in water at 50 °C overa period of 30 days in the dark.
[14C-friazole]Flutriafoaln d [14C-carbinol]flutriafol were applied at a rateequivalent to 94 g ai ha-1 to samples of dry sandy loam soil distributed asa thin layer on 10 cm diameter glass plates. Samples were exposed tonatural sunlight for 30 days or to alternating periods of 'black light' anddarkness for 7 days. Recovery was 60-47% of applied radioactivity after7 days artificial illumination and 74-85% after exposure to natural sunlight.All degradation products accounted for ＜5 %of the total appliedradioactivity (PSD, 1996). |
Flutriafol Preparation Products And Raw materials
| Preparation Products | 2-Fluorobenzoic acid |
