Formononetin CAS 485-72-3
Introduction：Basic information about Formononetin CAS 485-72-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Formononetin Basic information
| Product Name: | Formononetin |
| Synonyms: | Formononetin (50 mg);red clover extract_formononetin;Flavosil;ForMonentin;Myconate;NSC 93360;ForMononetin (ForMononetol);ForMoononetin |
| CAS: | 485-72-3 |
| MF: | C16H12O4 |
| MW: | 268.26 |
| EINECS: | 207-623-9 |
| Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;The group of Astralosides;Iso-Flavones |
| Mol File: | 485-72-3.mol |
Formononetin Chemical Properties
| Melting point | 256-260 °C |
| Boiling point | 331.43°C (rough estimate) |
| density | 1.1529 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4350 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 100 mg/ml). |
| pka | 6.99±0.20(Predicted) |
| form | Powder |
| color | White to light beige |
| λmax | 300nm(EtOH)(lit.) |
| Merck | 14,4244 |
| BRN | 237979 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | SKIN PROTECTING ANTIOXIDANT SKIN CONDITIONING - MISCELLANEOUS |
| InChI | 1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3 |
| InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O |
| LogP | 1.7 at 25℃ |
| CAS DataBase Reference | 485-72-3(CAS DataBase Reference) |
| EPA Substance Registry System | 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 37/39-26-36 |
| WGK Germany | 3 |
| RTECS | DJ3100114 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solids |
| Description | Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5 |
| Chemical Properties | off-white powder |
| Uses | An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen. |
| Uses | Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. |
| Uses | Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity. |
| Definition | ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-). |
| General Description | Formononetin belongs to the isoflavones class of polyphenols. |
| Flammability and Explosibility | Not classified |
| Biochem/physiol Actions | Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. |
| References | [1] TAO NIE. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity[J]. British Journal of Pharmacology, 2018, 175 9: 1439-1450. DOI:10.1111/bph.14139 [2] JYOTI GAUTAM. Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss.[J]. British Journal of Nutrition, 2017, 117 5: 645-661. DOI:10.1017/s0007114517000149 [3] JEONG-EUN HUH . Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways[J]. International immunopharmacology, 2011, 11 1: Pages 46-54. DOI:10.1016/j.intimp.2010.10.003 [4] SAMANTHA KAH LING ONG. Focus on Formononetin: Anticancer Potential and Molecular Targets.[J]. Cancers, 2019. DOI:10.3390/cancers11050611 [5] ZHENGZHAO LI . Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons[J]. Biomedicine & Pharmacotherapy, 2018, 106: Pages 349-354. DOI:10.1016/j.biopha.2018.06.041 |
Formononetin Preparation Products And Raw materials
| Raw materials | 3-(4-methoxyphenyl)-7-phenylmethoxychromen-4-one-->1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone-->2-Bromo-4'-methoxyacetophenone |
