FORMOTHION CAS 2540-82-1
Introduction：Basic information about FORMOTHION CAS 2540-82-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
FORMOTHION Basic information
| Product Name: | FORMOTHION |
| Synonyms: | S-[2-(FORMYLMETHYLAMINO)-2-OXOETHYL] O,O-DIMETHYL DITHIOPHOSPHATE;S-[2-(FORMYLMETHYLAMINO)-2-OXOETHYL]-O,O-DIMETHYL-PHOSPHORODITHIONATE;O,O-DIMETHYL S-(N-FORMYL-N-METHYL-CARBAMOYLMETHYL)PHOSPHORODITHIOATE;Formothionsolution in xylene PESTANAL, s;Formothion 0.1;ForMothion solutio;Anthio 33;nthio 25 |
| CAS: | 2540-82-1 |
| MF: | C6H12NO4PS2 |
| MW: | 257.27 |
| EINECS: | 219-818-6 |
| Product Categories: | Peptide |
| Mol File: | 2540-82-1.mol |
FORMOTHION Chemical Properties
| Melting point | 25.5℃ |
| Boiling point | 317.8±52.0 °C(Predicted) |
| density | 1.361 g/cm3 (20 ºC) |
| vapor pressure | 1.13 x 10-4 Pa (20 °C) |
| refractive index | 1.5541 (589.3 nm 20℃) |
| Fp | 25 °C |
| storage temp. | 2-8°C |
| Water Solubility | 2600 mg l-1(24 °C) |
| pka | -1.79±0.70(Predicted) |
| form | solid |
| biological source | rabbit |
| BRN | 5942199 |
| Major Application | agriculture |
| InChI | 1S/C6H12NO4PS2/c1-7(5-8)6(9)4-14-12(13,10-2)11-3/h5H,4H2,1-3H3 |
| InChIKey | AIKKULXCBHRFOS-UHFFFAOYSA-N |
| SMILES | [H]C(=O)N(C)C(=O)CSP(=S)(OC)OC |
| CAS DataBase Reference | 2540-82-1(CAS DataBase Reference) |
| EPA Substance Registry System | Formothion (2540-82-1) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 21/22-36/38-20/21/22-10 |
| Safety Statements | 36/37-36-26 |
| RIDADR | 3018 |
| WGK Germany | 3 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Asp. Tox. 1 Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT RE 2 Inhalation STOT SE 3 |
| Hazardous Substances Data | 2540-82-1(Hazardous Substances Data) |
| Toxicity | LD50 in rats, rabbits (mg/kg): 350, 410 orally (Liesche) |
| Description | Formothion is a pale yellow liquid or crystalline mass,decomposes on distillation, mp 25–26 ?C, vp 0.113 mPa(20 ?C). It is poorly soluble in water (2.6 g/L at24 ?C) and miscible with most organic solvents, exceptaliphatic hydrocarbons. Log Kow = 1.47. Formothion ishydrolyzed in aqueous media to dimethoate (activation)and dimethoate carboxylic acid (degradation): DT50 (23 ?C)at pH 3–9 is less than 1 d. |
| Chemical Properties | Formothion is an odorless, yellowish viscousoil or crystalline mass. |
| Chemical Properties | Yellow liquid.Insoluble inwater; miscible with common organic solvents. |
| Uses | Acaricide, systemic insecticide. |
| Uses | Formothion is used to control sucking pests and internally feedinglarvae in a variety of crops. |
| Definition | ChEBI: Formothion is a dicarboximide. |
| General Description | Viscous yellow oil or a crystalline mass. Used as an insecticide and acaricide on crops and ornamentals. Not presently produced commercially in the U.S. |
| Air & Water Reactions | hydrolyzed by water especially under alkaline conditions. [EPA, 1998]. |
| Reactivity Profile | Organophosphates, such as FORMOTHION, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. |
| Hazard | Cholinesterase inhibitor. |
| Health Hazard | FORMOTHION is one of the least toxic systemic organophosphates. FORMOTHION is a compound of low to moderate toxicity. It causes the depression of cholinesterase, leading to accumulation of acetylcholine in the nervous system, which is believed to be responsible for the symptoms. |
| Fire Hazard | When heated to decomposition, FORMOTHION emits very toxic fumes of nitrogen oxides, phosphorus oxides and sulfur oxides. FORMOTHION is an organophosphorus insecticide. Some of these materials may burn but none of them ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Avoid alkaline pesticides; hydrolyzed by water especially under alkaline conditions. |
| Agricultural Uses | Insecticide, Acaricide: Formothion is a systemic and contact insecticideused to control spider mites, aphids, psyllids, mealy bugs,whiteflies, jassids, leaf miners, ermine moths, and fruitflies. It is used on tree fruits, vines, olives, hops, cereals,sugar cane, rice. Formothion is available as an emulsifiableconcentrate and an ultra-low-volume spray. A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EUcountries |
| Trade name | AFLIX®; ANTHIO®; ANTIO®; CP53926®; S 6900®; SAN 244 I®; SAN 6913 I®; SAN71071®; SPENCER S-6900®; VEL 4284® |
| Safety Profile | Poison by ingestion, inhalation, sh contact, and intravenous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx. See also ESTERS. |
| Potential Exposure | Formothion is an insecticide and acar icide for use on crops and ornamentals. Formothion is notcurrently produced commercially in the U.S. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, beginrescue breathing (using universal precautions, includingresuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. Keepvictim quiet and maintain normal body temperature. Effectsmay be delayed; keep victim under observation. |
| Metabolic pathway | Formothion is broken down in aqueous solution to approximately equalamounts of dimethoate and dimethoate carboxylic acid, the first of whichis an activation step and the latter a degradative one. All studies whichhave investigated the fate of formothion in biological systems haveidentified these two metabolites but there is evidence that their formationis purely base-catalysed and not enzyme-catalysed. In this respect, theamide group of formothion is much more labile than that of dimethoatesince dimethoate carboxylic acid has only been reported in metabolicstudies and is not formed by base-catalysed hydrolysis of dimethoate. |
| storage | Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from alkaline materials. Wherepossible, automatically pump liquid from drums or otherstorage containers to process containers. |
| Shipping | UN3018 Organophosphorus pesticides, liquid,toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. |
| Degradation | Formothion is hydrolysed by water to dimethoate (2) and dimethoatecarboxylic acid (3). Dilute solutions in non-polar organic solvents arestable (PM). El-Oshar and Dauterman (1977) investigated the hydrolysisof [O-14C-methyl]formothion in 1.0 M phosphate buffer at pH valuesbetween 5.5 and 8.0 at 37 °C. The amounts of unchanged formothion andproducts were assessed after 30 min. At all pH values the amounts ofdimethoate (2) and dimethoate carboxylic acid (3) were approximatelyequal, indicating that the rate of attack by the hydroxyl ion was equal atboth carbonyl groups. The rate of hydrolysis was pH dependent with16.4% hydrolysis at pH 5.5, 65.2% hydrolysis at pH 7.0 and 96.7%hydrolysis at pH 8.0 after 30 min. The route leading to dimethoate carboxylicacid would yield N-methylformamide (4) as the additional product.A suggested route for the base-catalysed hydrolysis of formothionis shown in Scheme 1. |
| Toxicity evaluation | The acute oralLD50 for rats is 365–500 mg/kg. Inhalation LC50 (4 h) forrats is 3.2 mg/L air. NOEL (2 y) for rats is 80 mg/kg diet(4 mg/kg/d). ADI is 0.02 mg/kg b.w. |
| Incompatibilities | Strong oxidizers may cause release oftoxic phosphorus oxides. Organophosphates, in the pres ence of strong reducing agents such as hydrides, may formhighly toxic and flammable phosphine gas. Keep awayfrom alkaline materials. |
| Waste Disposal | In accordance with 40CFR165 recommendations for the disposal of pesticides andpesticide containers. Must be disposed properly by follow ing package label directions or by contacting your local or federal environmental control agency, or by contactingyour regional EPA office. |
FORMOTHION Preparation Products And Raw materials
