FORSYTHOSIDE A CAS 79916-77-1

Introduction：Basic information about FORSYTHOSIDE A CAS 79916-77-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

FORSYTHOSIDE A Basic information

• Product Name: FORSYTHOSIDE A
• Synonyms: 2-(3,4-Dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-4-O-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]carbonyl-β-D-glucopyranoside;FORSYTHOSIDE A;Forsythiaside A;Forsythiaside;b-D-Glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-a-L-Mannopyranosyl)-,4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate];Forsythoside A, 98%, from Forsythia suspensa;Forsythoside A 79916-77-1;β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
• CAS: 79916-77-1
• MF: C29H36O15
• MW: 624.59
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 79916-77-1.mol

FORSYTHOSIDE A Chemical Properties

• Melting point: >127°C (subl.)
• Boiling point: 911.9±65.0 °C(Predicted)
• density: 1.60±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 9.31±0.10(Predicted)
• color: Off-White to Light Beige
• InChIKey: DTOUWTJYUCZJQD-LAFJTCKFNA-N
• SMILES: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO[C@@H]4O[C@H]([C@@H]([C@H]([C@H]4O)O)O)C)OC(=O)\C=C\c3cc(c(cc3)O)O)O)O)OCCc2cc(c(cc2)O)O
• CAS DataBase Reference: 79916-77-1

Safety Information

• WGK Germany: WGK 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

FORSYTHOSIDE A Usage And Synthesis

Overview

Forsythiaside A is the phenylethanol glycoside component isolated from Forsythia. It has pharmacological effects such as antibacterial, antiviral, antioxidant, anti-infective and antipyretic. It is mainly used for content determination, identification, and pharmacological experiment and so on.

Chemical Properties

This product appears as white crystalline powder. It is easily soluble in water, ethanol and methanol, but insoluble in ether and chloroform.

Pharmacological effects

Forsythoside A has not only antibacterial, anti-infective and antipyretic effects, but also good anti-virus and antioxidant effects.

Preparation

Extract 40 g of crushed forsythia leaves with 1200 mL 55% ethanol (volume fraction) at 74 ° C for 50 min, filter and extract twice. The filtrate was combined and concentrated under reduced pressure at 50 °C to recycle the ethanol, obtaining 665 mL of concentrated solution. 35 mL of absolute ethanol was added to give a forsythia leaf extract containing 5% ethanol (volume fraction). The forsythia leaf extract was adsorbed on a 2.6 cm x 25 cm AB-8 resin column and eluted with 50% ethanol to obtain a forsythia leaf extract. The extract of forsythia leaf was extracted for three times with water-saturated n-butanol. Recycle the n-butanol, and dry to obtain crude product. The crude product was separated in 8 cm x 50 cm C18 reverse phase silica gel column chromatography through elution with 30% methanol. Collect the eluent and obtain the pure compound of forsythoside A under reduced pressure.

Application

It can be used for content determination, identification and pharmacological experiments.

Uses

Forsythoside A is used as an antiinflammatory agent in traditional Chinese medicine.

Definition

ChEBI: Forsythiaside is a hydroxycinnamic acid.

Biological Activity

extracted from forsythia suspense (thunb.) vahl dried fruit;store the product in sealed, cool and dry condition

in vivo

Forsythiaside A (15-60 mg/kg; single dose; oral) improves OVA-induced asthma models in mice, dose-dependently activates Nrf2/HO-1 signaling, and attenuates OVA-induced lung histopathology^[3].